Detailed Information on Publication Record
2005
The effects of chronic corticosterone treatment on hippocampal astrocyte numbers in male and female rats
ŠLAIS, Karel, Nikola Jane BRIDGES and Eva SYKOVÁBasic information
Original name
The effects of chronic corticosterone treatment on hippocampal astrocyte numbers in male and female rats
Name in Czech
Efekt chronického podávání kortikosteronu na počet astrocytů v hipokampu u samců a samic potkana
Authors
ŠLAIS, Karel (203 Czech Republic, guarantor), Nikola Jane BRIDGES (826 United Kingdom of Great Britain and Northern Ireland) and Eva SYKOVÁ (203 Czech Republic)
Edition
Psychiatrie, Praha, Tigis s.r.o. 2005, 1211-7579
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/05:00013591
Organization unit
Faculty of Medicine
Keywords in English
corticosterone; astrocyte; rat; chronic stress
Tags
Změněno: 31/1/2005 15:44, MUDr. Mgr. Karel Šlais, Ph.D.
V originále
The hippocampus is widely reported to be involved in the response to stress. High glucocorticoid serum levels have been associated with depression, post-traumatic stress disorder, and some aspects of cognitive dysfunction in humans. Much of the research conducted has focused primarily on the use of male animals, with little investigation of possible sex differences. The aim of the present study was to assess whether chronic (21 days) corticosterone treatment produces changes in hippocampal astrocyte numbers in male and female rats.Corticosterone treatment produced a dose-dependent increase in the number of astrocytes in the CA1 region when compared to both controls and placebo-treated animals. No difference was found between control and placebo animals, suggesting that pellet implantation itself had no effect and that all astrocyte alterations were a result of corticosterone application. The effect of both doses of corticosterone did not differ between males and females.
In Czech
Hipokampus je struktura úzce souvisejiící s odpovědí organismu na stres. Vysoké hladiny glukokortikoidů jsou dávány do vztahu s depresí, PTSD a některými kognitivními dysfunkcemi.Většina dosud prováděného výzkumu se zaměřovala především na samce, s malým důrazem na pohlavní rozdíly. Cílem studie bylo ověřit, zfa chronické (21 dnů) podávání kortikosteronu vyvolá změny v počtu astrocytů v hipokampu u samců a samic potkana. Podávání kortikosteronu zvýšilo na dávce závisle počet astrocytů v CA1 oblasti hipokampu ve srovnání s placebem i kontrolou. Efekt obou dávek kortikosteronu u samců a samic se nelišil.
Links
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