J 2005

Novel flavivirus or new lineage of West Nile virus, Central Europe

BAKONYI, Tamás, Zdeněk HUBÁLEK, Ivo RUDOLF and Norbert NOWOTNY

Basic information

Original name

Novel flavivirus or new lineage of West Nile virus, Central Europe

Name in Czech

Nový flavivirus nebo nová genomická linie viru West Nile ve střední Evropě

Authors

BAKONYI, Tamás, Zdeněk HUBÁLEK, Ivo RUDOLF and Norbert NOWOTNY

Edition

Emerging Infectious Diseases, Atlanta, CDC, 2005, 1080-6040

Other information

Type of outcome

Článek v odborném periodiku

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 5.308

Organization unit

Faculty of Science

UT WoS

000226856900005

Keywords in English

Rabensburg; south Moravia; mosquito-borne virus; West Nile virus; sequencing; complete genome

Tags

Změněno: 9/3/2005 10:02, prof. RNDr. Zdeněk Hubálek, DrSc.

Abstract

V originále

A flavivirus (strain 97-103) was isolated from Culex pipens mosquitoes in 1997 following floods in South Moravia, Czech Republic. The strain exhibited close antigenic relationship to West Nile virus (WNV) prototype strain Eg-101 in a cross-neutralization test. In this study, mouse pathogenicity characteristics and the complete nucleotide and putative amino acid sequences of isolate 97-103, named Rabensburg virus (RabV) after a nearby Austrian city, were determined. RabV shares only 75%-77% nucleotide identity and 89%-90% amino acid identity with representative strains of WNV lineages 1 and 2. Another RabV strain (99-222) was isolated in the same location two years later; it showed >99% nucleotide identity to strain 97-103. Phylogenetic analyses of RabV, WNV strains, and other members of the Japanese encephalitis virus (JEV) complex clearly demonstrated that RabV is either a new (third) lineage of WNV or a novel flavivirus of the JEV group.

Links

GA206/03/0726, research and development project
Name: Ekologie emergentních mikroorganismů přenosných hematofágními členovci