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KAŇKOVÁ, Kateřina and Katarina ŠEBEKOVÁ. Genetic variability in the RAGE gene: Possible implications for nutrigenetics, nutrigenomics and understanding the susceptibility to diabetic complications. Molecular Nutrition & Food Research. Germany: Wiley-VCH Verlag, 2005, vol. 49, No 7, p. 700-709. ISSN 1613-4125.
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Basic information
Original name Genetic variability in the RAGE gene: Possible implications for nutrigenetics, nutrigenomics and understanding the susceptibility to diabetic complications
Name in Czech Genetická variabilita v RAGE genu: Možné dsledky pro nutrigenetiku, nutrigenomiku a pochopení genetické dispozice k rozvoji diabetických komplikací
Authors KAŇKOVÁ, Kateřina (203 Czech Republic, guarantor) and Katarina ŠEBEKOVÁ (703 Slovakia).
Edition Molecular Nutrition & Food Research, Germany, Wiley-VCH Verlag, 2005, 1613-4125.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30202 Endocrinology and metabolism
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.071
RIV identification code RIV/00216224:14110/05:00012419
Organization unit Faculty of Medicine
UT WoS 000230671600010
Keywords in English AGEs; diabetes; glycoxidation; nutrigenetics; RAGE
Tags AGEs, Diabetes, glycoxidation, nutrigenetics, RAGE
Changed by Changed by: prof. MUDr. Kateřina Kaňková, Ph.D., učo 2524. Changed: 23/6/2009 15:19.
Abstract
Complex chemical processes called non-enzymatic glycation and glycoxidation are one of the interesting examples of potentially harmful interaction between nutrition and disease. This review summarizes factors influencing the extent of glycoxidation in health and disease and especially focuses on the role of genetic variability in glycoxidation-related genes in disease and diet-related pathogenesis. Possible interaction between genetic variability in relevant loci and dietary Advanced Glycation End products (AGEs) is considered. As AGEs possess a wide range of chemical and biological effects, the interindividual functional variability in systems dealing with glycoxidation could have a significant nutrigenomic and nutrigenetic consequences.
Abstract (in Czech)
Pehledná práce shrnuje dosavadní poznatky podporující roli genetické variability v RAGE genu ve vztahu k rozvoji diabetických komplikací a rovnez možné dsledky této variability pro nutrigenetiku a nutrigenomiku.
Links
GP303/02/D127, research and development projectName: Vztah genetické variability antioxidačního systému k pozdním komplikacím diabetu mellitu
Investor: Czech Science Foundation, Relationship between genetic variability of antioxidant system and late complications of diabetes mellitus
LZ1K03019, research and development projectName: Zlepšení hojení ran u pacientů s diabetem: preklinické ověření role proteinu MSF
Investor: Ministry of Education, Youth and Sports of the CR
MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
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