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@article{571409,
author = {Michálek, Jaroslav and Büchler, Tomáš and Hájek, Roman and Büchler, Tomáš and Hájek, Roman},
article_location = {Praha},
article_number = {53},
keywords = {T lymphocyte; Cancer; Therapy},
language = {eng},
issn = {0862-8408},
journal = {Physiological Research},
title = {T Lymphocyte Therapy of Cancer},
url = {biomed.cas.cz},
volume = {53},
year = {2004}
}
TY - JOUR
ID - 571409
AU - Michálek, Jaroslav - Büchler, Tomáš - Hájek, Roman - Büchler, Tomáš - Hájek, Roman
PY - 2004
TI - T Lymphocyte Therapy of Cancer
JF - Physiological Research
VL - 53
IS - 53
SP - 463-469
EP - 463-469
PB - Institute of Physiology,Academy of Sciences of the Czech Republic
SN - 08628408
KW - T lymphocyte
KW - Cancer
KW - Therapy
UR - biomed.cas.cz
N2 - The rationale for the use of T lymphocytes to fight cancer is the immunogenicity of tumor cells.T cells are capable to recognize and finally to kill tumor cells.Adoptiveč cell transfer therapies provide the opportunity to overcome tolerogenic mechanisms by enabling the selection and activation of highly reactive T cell subpopulations and bymanipulation of the host environment into which the T cell are introduced. The aim of this article is to review the possibilities,limitations and recent clinical experience with this novel anticancer treatment,namely with adoptive immunotherapy using antigen-specific T cells.
ER -
MICHÁLEK, Jaroslav, Tomáš BÜCHLER and Roman HÁJEK. T Lymphocyte Therapy of Cancer. \textit{Physiological Research}. Praha: Institute of Physiology,Academy of Sciences of the Czech Republic, 2004, vol.~53, No~53, p.~463-469. ISSN~0862-8408.
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