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@inproceedings{571744,
author = {Matějková, Petra and Šmajs, David},
address = {Brno},
booktitle = {Abstrakta 47. Studentské vědecké konference},
edition = {2003},
keywords = {comparative genomics; Treponema pallidum},
language = {cze},
location = {Brno},
pages = {15 - 16},
publisher = {Lékařská fakulta MU},
title = {Komparativní genomika patogenních poddruhů Treponema pallidum},
year = {2003}
}
TY - JOUR
ID - 571744
AU - Matějková, Petra - Šmajs, David
PY - 2003
TI - Komparativní genomika patogenních poddruhů Treponema pallidum
PB - Lékařská fakulta MU
CY - Brno
KW - comparative genomics
KW - Treponema pallidum
N2 - As a result of DNA microarray comparisons, 25 genes (13 with stronger and 6 with weaker signal in pertenue strains and 6 control genes with similar signal in both subspecies examined) were selected and sequenced. Altogether, 24083 nucleotides (2.12% of the genome) were sequenced in 3 pertenue strains and control Nichols. No region of extensive sequence heterogeneity was detected. However, 15 different single nucleotide polymorfisms (SNP) were identified: 3 SNPs in Gauthier strain, 14 in Samoan D and 15 SNPs in CDC-2. Ten (out of 15) SNPs cause amino acid changes. SNPs common for all pertenue strains as well as SNPs specific for each individual strain will allow to use these nucleotide polymorfisms to design sequence specific PCR diagnostics of these strains.
ER -
MATĚJKOVÁ, Petra and David ŠMAJS. Komparativní genomika patogenních poddruhů Treponema pallidum (Comparative genomics of pathogenic Treponema pallidum subspecies). Online. In \textit{Abstrakta 47. Studentské vědecké konference}. 2003rd ed. Brno: Lékařská fakulta MU, 2003. p.~15 - 16, 1 pp. [citováno 2024-04-24]
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