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@inproceedings{571748,
author = {Matějková, Petra and Šmajs, David and Norris, SJ and Weinstock, GM},
address = {Brno},
booktitle = {Sborník abstraktů XII. konference mladých mikrobiologů Tomáškovy dny 2003},
edition = {2003},
keywords = {comparative genomics; Treponema pallidum},
language = {cze},
location = {Brno},
pages = {14-14},
publisher = {Lékařská fakulta MU},
title = {Komparativní genomika patogenních poddruhů treponema pallidum},
year = {2003}
}
TY - JOUR
ID - 571748
AU - Matějková, Petra - Šmajs, David - Norris, SJ - Weinstock, GM
PY - 2003
TI - Komparativní genomika patogenních poddruhů treponema pallidum
PB - Lékařská fakulta MU
CY - Brno
KW - comparative genomics
KW - Treponema pallidum
N2 - As a result of DNA microarray comparisons, 25 genes (13 with stronger and 6 with weaker signal in pertenue strains and 6 control genes with similar signal in both subspecies examined) were selected and sequenced. Altogether, 24083 nucleotides (2.12% of the genome) were sequenced in 3 pertenue strains and control Nichols. No region of extensive sequence heterogeneity was detected. However, 15 different single nucleotide polymorfisms (SNP) were identified: 3 SNPs in Gauthier strain, 14 in Samoan D and 15 SNPs in CDC-2. Ten (out of 15) SNPs cause amino acid changes. SNPs common for all pertenue strains as well as SNPs specific for each individual strain will allow to use these nucleotide polymorfisms to design sequence specific PCR diagnostics of these strains.
ER -
MATĚJKOVÁ, Petra, David ŠMAJS, SJ NORRIS and GM WEINSTOCK. Komparativní genomika patogenních poddruhů treponema pallidum (Comparative genomics of pathogenic subspecies of Treponema pallidum). In \textit{Sborník abstraktů XII. konference mladých mikrobiologů Tomáškovy dny 2003}. 2003rd ed. Brno: Lékařská fakulta MU, 2003, p.~14.
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