SMILEK, Pavel, Rom KOSTŘICA, Jan ROTTENBERG, Karel VESELÝ and Ladislav DUŠEK. PREDICTIVE PARAMETERS OF THE PHARYNX AND SUPRAGLOTTIC CARCINOMAS. In Sborník abstrakt a program 68. kongresu České spol. pro otorinolaryngologii a chir. hlavy a krku. Brno: Medica Publishing and consulting s.r.o., 2005, p. 111. ISBN 80-239-5112-2.
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Basic information
Original name PREDICTIVE PARAMETERS OF THE PHARYNX AND SUPRAGLOTTIC CARCINOMAS
Name in Czech Prediktivní parametry karcinomu faryngu a supraglottis
Name (in English) PREDICTIVE PARAMETERS OF THE PHARYNX AND SUPRAGLOTTIC CARCINOMAS
Authors SMILEK, Pavel, Rom KOSTŘICA, Jan ROTTENBERG, Karel VESELÝ and Ladislav DUŠEK.
Edition Brno, Sborník abstrakt a program 68. kongresu České spol. pro otorinolaryngologii a chir. hlavy a krku, p. 111-111, 2005.
Publisher Medica Publishing and consulting s.r.o.
Other information
Original language Czech
Type of outcome Proceedings paper
Field of Study 30200 3.2 Clinical medicine
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Medicine
ISBN 80-239-5112-2
Keywords in English head and neck cancer; prognosis; p53; DNA flow-cytometry
Tags DNA flow-cytometry, head and neck cancer, p53, prognosis
Changed by Changed by: doc. MUDr. Pavel Smilek, Ph.D., učo 1801. Changed: 22/6/2005 08:16.
Abstract
The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis. Besides routine examinations, flow cytometric analysis of was performed, p53 and Ki-67 markers were established by means of immunohistochemistry. Furthermore mitotic and apoptotic index were established. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Early progressed cases have typically decreased SPF fraction combined with increased mitotic activity.
Abstract (in English)
The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis. Besides routine examinations, flow cytometric analysis of was performed, p53 and Ki-67 markers were established by means of immunohistochemistry. Furthermore mitotic and apoptotic index were established. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Early progressed cases have typically decreased SPF fraction combined with increased mitotic activity.
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