GALLO, Jiří, Milan KOLÁŘ, Anthony V. FLORSCHÜTZ, Radek NOVOTNÝ, Roman PANTŮČEK a Michaela KESSELOVÁ. In vitro testing of vancomycin - gentamicin loaded bone cement to prevent prosthetic joint infection. Biomedical Papers. Olomouc: Palacký University, 2005, roč. 149, č. 1, s. 153-158. ISSN 1213-8118. |
Další formáty:
BibTeX
LaTeX
RIS
@article{573853, author = {Gallo, Jiří and Kolář, Milan and Florschütz, Anthony V. and Novotný, Radek and Pantůček, Roman and Kesselová, Michaela}, article_location = {Olomouc}, article_number = {1}, keywords = {Prosthetic joint infection; Polymethylmethacrylate; Antibiotic loaded cement; Vancomycin;Gentamicin; Staphylococcus aureus; Staphylococcus epidermidis}, language = {eng}, issn = {1213-8118}, journal = {Biomedical Papers}, title = {In vitro testing of vancomycin - gentamicin loaded bone cement to prevent prosthetic joint infection}, url = {http://publib.upol.cz/~obd/fulltext/Biomed/2005/1/153.pdf}, volume = {149}, year = {2005} }
TY - JOUR ID - 573853 AU - Gallo, Jiří - Kolář, Milan - Florschütz, Anthony V. - Novotný, Radek - Pantůček, Roman - Kesselová, Michaela PY - 2005 TI - In vitro testing of vancomycin - gentamicin loaded bone cement to prevent prosthetic joint infection JF - Biomedical Papers VL - 149 IS - 1 SP - 153-158 EP - 153-158 PB - Palacký University SN - 12138118 KW - Prosthetic joint infection KW - Polymethylmethacrylate KW - Antibiotic loaded cement KW - Vancomycin;Gentamicin KW - Staphylococcus aureus KW - Staphylococcus epidermidis UR - http://publib.upol.cz/~obd/fulltext/Biomed/2005/1/153.pdf N2 - Sepsis is a greatly feared complication of total joint arthroplasty. One key question is how to prevent periopera-tive bacterial adherence, and therefore the potential for infectious complications. The objective of our study was to appraise the emerging capacity of staphylococcal survival on prosthetic materials and to analyze the in vitro eects of gentamicin and vancomycin loaded polymethylmethacrylate (PMMA) cement on bacterial adherence and growth. Hospital acquired staphylococcal strains were systematically inoculated on four orthopedic materials (ultrahigh mo-lecular weight polyethylene, PMMA without antibiotic, commercially produced PMMA loaded with gentamicin, and manually mixed PMMA loaded with gentamicin and vancomycin). Staphylococci were identied using culture and biochemical tests. The inoculated material was allowed to incubate in a liquid broth growth media and subsequently prepared for scanning electron microscopy and bacterial growth quantication. Materials without antibiotics showed evidence of staphylococcal growth. PMMA loaded with only gentamicin grew methicillin-resistant Staphylococcus aureus. Gentamicin-vancomycin loaded PMMA completely inhibited any bacterial growth.Low-dose gentamicin-vancomycin loaded PMMA prevents staphylococcal colonization better than commercially manufactured PMMA loaded with gentamicin. We recommend this combination in high-risk procedures and revision surgeries requiring bone cement. ER -
GALLO, Jiří, Milan KOLÁŘ, Anthony V. FLORSCHÜTZ, Radek NOVOTNÝ, Roman PANTŮČEK a Michaela KESSELOVÁ. In vitro testing of vancomycin - gentamicin loaded bone cement to prevent prosthetic joint infection. \textit{Biomedical Papers}. Olomouc: Palacký University, 2005, roč.~149, č.~1, s.~153-158. ISSN~1213-8118.
|