ŠMARDOVÁ, Jana, Alice NEMAJEROVÁ, Jarmila NAVRÁTILOVÁ, Pierre JURDIC and Jan ŠMARDA. CBP sensitizes v-myb-transformed monoblasts to differentiation inducers. Differentiation. Malden, USA: Blackwell Publishing, 2005, vol. 73, No 5, p. 222-232. ISSN 0301-4681. |
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@article{573859, author = {Šmardová, Jana and Nemajerová, Alice and Navrátilová, Jarmila and Jurdic, Pierre and Šmarda, Jan}, article_location = {Malden, USA}, article_number = {5}, keywords = {CBP; v-Myb; hematopoiesis; differentiation; monoblasts}, language = {eng}, issn = {0301-4681}, journal = {Differentiation}, title = {CBP sensitizes v-myb-transformed monoblasts to differentiation inducers}, volume = {73}, year = {2005} }
TY - JOUR ID - 573859 AU - Šmardová, Jana - Nemajerová, Alice - Navrátilová, Jarmila - Jurdic, Pierre - Šmarda, Jan PY - 2005 TI - CBP sensitizes v-myb-transformed monoblasts to differentiation inducers JF - Differentiation VL - 73 IS - 5 SP - 222-232 EP - 222-232 PB - Blackwell Publishing SN - 03014681 KW - CBP KW - v-Myb KW - hematopoiesis KW - differentiation KW - monoblasts N2 - CREB-binding protein (CBP) regulates gene expression by binding to certain components of basal transcription machinery and by histone acetylation. In addition, it integrates various cellular signaling pathways through binding to multiple transcription factors, including the Myb proteins. We report in this study that CBP can partially suppress function of the v-Myb oncoprotein in leukemic cells. Although originally described as activator of v-Myb function, we show that CBP can also act as v-Myb suppressor. Ectopic expression of murine CBP in v-Myb-transformed chicken monoblasts reduced transcriptional activation abilities of the v-Myb protein and increased sensitivity to differentiation inducers such as phorbol ester or trichostatin A. In addition, exogenous CBP affected morphology of differentiated cells derived from BM2 monoblasts. Altogether, these results indicate that cellular context is an important factor to determine whether CBP will activate or suppress the protein it targets. ER -
ŠMARDOVÁ, Jana, Alice NEMAJEROVÁ, Jarmila NAVRÁTILOVÁ, Pierre JURDIC and Jan ŠMARDA. CBP sensitizes v-myb-transformed monoblasts to differentiation inducers. \textit{Differentiation}. Malden, USA: Blackwell Publishing, 2005, vol.~73, No~5, p.~222-232. ISSN~0301-4681.
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