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@inproceedings{575461, author = {Šmarda, Jan and Šmardová, Jana and Nemajerová, Alice and Navrátilová, Jarmila}, address = {Oslo}, booktitle = {Functional Genomics and Disease}, keywords = {CBP; Myb; differentiation; trichostatin A; TPA}, language = {eng}, location = {Oslo}, isbn = {JB484MB001322OS}, pages = {114-115}, publisher = {European Science Foundation}, title = {CREB-binding protein sensitizes v-myb-transformed monoblasts to differentiation inducers}, year = {2005} }
TY - JOUR ID - 575461 AU - Šmarda, Jan - Šmardová, Jana - Nemajerová, Alice - Navrátilová, Jarmila PY - 2005 TI - CREB-binding protein sensitizes v-myb-transformed monoblasts to differentiation inducers PB - European Science Foundation CY - Oslo SN - JB484MB001322OS KW - CBP KW - Myb KW - differentiation KW - trichostatin A KW - TPA N2 - CREB-binding protein (CBP) regulates gene expression by binding to certain components of basal transcription machinery and by histone acetylation. In addition, it integrates various cellular signaling pathways through binding to multiple transcription factors, including the Myb proteins. We report in this study that CBP can partially suppress function of the v-Myb oncoprotein in leukemic cells. Although originally described as activator of v-Myb function, we show that CBP can also act as v-Myb suppressor. Ectopic expression of murine CBP in v-Myb-transformed chicken monoblasts reduced transcriptional activation abilities of the v-Myb protein and increased sensitivity to differentiation inducers such as phorbol ester or trichostatin A. In addition, exogenous CBP affected morphology of differentiated cells derived from BM2 monoblasts. Altogether, these results indicate that cellular context is an important factor to determine whether CBP will activate or suppress the protein it targets. ER -
ŠMARDA, Jan, Jana ŠMARDOVÁ, Alice NEMAJEROVÁ and Jarmila NAVRÁTILOVÁ. CREB-binding protein sensitizes v-myb-transformed monoblasts to differentiation inducers. In \textit{Functional Genomics and Disease}. Oslo: European Science Foundation, 2005, p.~114-115. ISBN~JB484MB001322OS.
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