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@article{576341,
author = {Šerý, Omar and Hrazdilová, Olga and Matalová, Eva and Ševčík, Pavel},
article_location = {Oxford, UK},
article_number = {4},
keywords = {gene; polymorphism; pain; gene therapy; molecular biology},
language = {eng},
issn = {1530-7085},
journal = {Pain Practice},
title = {PAIN RESEARCH UPDATE FROM GENETIC POINT OF VIEW},
volume = {5},
year = {2005}
}
TY - JOUR
ID - 576341
AU - Šerý, Omar - Hrazdilová, Olga - Matalová, Eva - Ševčík, Pavel
PY - 2005
TI - PAIN RESEARCH UPDATE FROM GENETIC POINT OF VIEW
JF - Pain Practice
VL - 5
IS - 4
SP - 341-348
EP - 341-348
PB - Blackwell Synergy
SN - 15307085
KW - gene
KW - polymorphism
KW - pain
KW - gene therapy
KW - molecular biology
N2 - Molecular biology investigates the genetic causes of many diseases. Currently, molecular biology in pain research lags behind the investigations of the molecular basis of mental disorders. A significant challenge in pain genetic research is the fact that pain involves emotional factors. Tools available for pain measurements and interindividual comparisons have been imperfect. Another problem relates to research ethics. Unlike animal studies, there is very limited ability to evoke experimental pain in a group of humans with precisely defined age, sex, medication and pain experience. Nevertheless, pain investigations at the gene level have commenced. Recent progress in molecular biology has enabled gene expression modulations in animal models using knock-out, oligo-antisense and viral vector techniques. These methods enable investigation, at molecular level, as to which of the approximate 30 thousand genes of the human genome might be involved in pain mediation, which of these are polymorphic and which polymorhisms are responsible for interindividual differences in pain perception. Recently, the genetic basis of familial hemiplegic migraine and congenital insensitivity to pain with anhidrosis have been shown. In the last six years, genetic pain research has focused on potential gene therapy for patients with chronic pain. Results of these studies are encouraging and potentially applicable to clinical practice in the near future.
ER -
ŠERÝ, Omar, Olga HRAZDILOVÁ, Eva MATALOVÁ a Pavel ŠEVČÍK. PAIN RESEARCH UPDATE FROM GENETIC POINT OF VIEW. \textit{Pain Practice}. Oxford, UK: Blackwell Synergy, 2005, roč.~5, č.~4, s.~341-348. ISSN~1530-7085.
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