Comparative study on the influence of methamphetamine and enzyme inducers on the activity of drug-metabolizing enzymes in the rat liver microsomes

MINAŘÍKOVÁ, Veronika, Eva HADAŠOVÁ, Werner SIEGMUND, Klaus-Uwe MORITZ and Eberhard SCHEUCH. Comparative study on the influence of methamphetamine and enzyme inducers on the activity of drug-metabolizing enzymes in the rat liver microsomes. In Sborník abstrakt. 55. česko-slovenských farmakologických dnů, 31.8.-2.9. 2005, Hradec Králové. první. Hradec Králové: Grafické studio, Olga Čermáková, 2005, p. 30-30. ISBN 80-86703-09-6.

Basic information

• Original name: Comparative study on the influence of methamphetamine and enzyme inducers on the activity of drug-metabolizing enzymes in the rat liver microsomes
• Name in Czech: Srovnávací studie vlivu metamfetaminu a enzymových induktorů na aktivitu metabolizujících enzymů v mikrosomech jater potkana
• Authors: MINAŘÍKOVÁ, Veronika, Eva HADAŠOVÁ, Werner SIEGMUND, Klaus-Uwe MORITZ and Eberhard SCHEUCH.
• Edition: první. Hradec Králové, Sborník abstrakt. 55. česko-slovenských farmakologických dnů, 31.8.-2.9. 2005, Hradec Králové, p. 30-30, 1 pp. 2005.
• Publisher: Grafické studio, Olga Čermáková

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• ISBN: 80-86703-09-6
• Keywords in English: methamphetamine; metabolic enzymes; microsomes; rat
• Tags: metabolic enzymes, methamphetamine, microsomes, rat

Abstract

In the present study there was studied the influence of methamphetamine on the activity of cytochromes P450 and N-acetyltransferase (NAT)in the rat liver microsomes in comparison with the effect of known enzyme inducers: phenobarbital, beta-naphtoflavone and dexamethazone. Methamphetamine significantly inhibited CYP2E1, but, on the other hand, it stimulated NAT. Other investigated enzymes were not significantly influenced.

Abstract (in Czech)

Byl studován vliv metamfetaminu na aktivitu cytochromů P450 a N-acetyltransferázy (NAT)v mikrosomech jater potkana ve srovnání s účinkem známých induktorů fenobarbitalu, beta-naftoflavonu a dexametazonu. Metamfetamin signifikantně inhiboval CYP2E1, ale měl naopak stimulační účinek na NAT. Ostatní studované enzymy výrazně ovlivněny nebyly.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.