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@inproceedings{580341,
author = {Zahradníčková, Eva and Souček, Karel and Horváth, Viktor and Šmarda, Jan},
address = {Budapest, Hungary},
booktitle = {13th Euroconference on Apoptosis},
keywords = {v-Myb; apoptosis; autophagy; camptohecin},
language = {eng},
location = {Budapest, Hungary},
isbn = {9632192737},
pages = {P-251},
publisher = {European Cell Death Organization},
title = {Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts},
year = {2005}
}
TY - JOUR
ID - 580341
AU - Zahradníčková, Eva - Souček, Karel - Horváth, Viktor - Šmarda, Jan
PY - 2005
TI - Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts
PB - European Cell Death Organization
CY - Budapest, Hungary
SN - 9632192737
KW - v-Myb
KW - apoptosis
KW - autophagy
KW - camptohecin
N2 - A damage of programmed cell death pathways is a frequent event during malignant transformation. In this study, we analyzed programmed cell daeth (PCD) in v-myb-transformed BM2 and human U937 promonocytes induced by arsenic trioxide,cycloheximide and camtothecin. The presence of functional v-Myb protein pre-determined the BM2 cells to autophagic pathway of PCD in response to the DNA-damaging agents. The absence of transactivating v-Myb protein allowed activation of PCD pathway marked by mitochondrial membrane depolarization and resulting in necrosis. the fact that the antiapoptotic function of the Myb protein can be overcome by alternative PCD pathway suggests that understanding of molecular mechanisms of autophagy could improve therapy of cancer cells suffering from defective apoptosis.
ER -
ZAHRADNÍČKOVÁ, Eva, Karel SOUČEK, Viktor HORVÁTH and Jan ŠMARDA. Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts. In \textit{13th Euroconference on Apoptosis}. Budapest, Hungary: European Cell Death Organization. p.~P-251, 1 pp. ISBN~9632192737. 2005.
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