Behavioural sensitization to methamphetamine stimulatory effects on locomotion: comparative study in mice and rats

LANDA, Leoš, Karel ŠLAIS, Mariana HANESOVÁ and Alexandra ŠULCOVÁ. Behavioural sensitization to methamphetamine stimulatory effects on locomotion: comparative study in mice and rats. Behavioural Pharmacology. London: Lippincott Williams & Wilkins, 2005, vol. 16, Suppl. 1, p. S55-S55, 1 pp. ISSN 0955-8810.

Basic information

• Original name: Behavioural sensitization to methamphetamine stimulatory effects on locomotion: comparative study in mice and rats
• Name in Czech: Behaviorální senzitizace ke stimulačním účinkům metamfetaminu na lokomoci: srovnávací studie a myší a potkanů
• Authors: LANDA, Leoš, Karel ŠLAIS, Mariana HANESOVÁ and Alexandra ŠULCOVÁ.
• Edition: Behavioural Pharmacology, London, Lippincott Williams & Wilkins, 2005, 0955-8810.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Spain
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.773
• Organization unit: Faculty of Medicine
• UT WoS: 000232603300171
• Keywords in English: behavioural sensitization; mice; rats; open field; methamphetamine
• Tags: behavioural sensitization, methamphetamine, mice, open field, rats
• Tags: International impact

Abstract

In the Experiment 1, the significant stimulatory MET effects on mouse locomotion were apparent after the first dose (2.5 mg/kg), and the significantly increased effect was measured after the repeated administration. In the Experiment 2, MET at the doses of 2.5 or 5 mg/kg stimulated ambulation of rats in the open field test, however after the repeated administration these effects were decreased (insignificantly after the lower and significantly after the higher dose), however, in both groups stereotypic nose rubbing occurred (stereotypies are defined as one of possible signs of behavioural sensitization, too). In the Experiment 3, the significant stimulatory effect on ambulation of rats measured after the first dose of MET at the dose of 0.5 mg/kg was significantly higher after the 8th dose.

Abstract (in Czech)

V Experimentu 1 byl zřejmý signifikantní stimulační vliv metamfetaminu na lokomoci myší po první dávce (2.5 mg/kg) a ještě k dalšímu signifikantnímu zvýšení došlo po opakované aplikaci. V Experimentu 2 akutní podání metamfetaminu v dávkách 2.5 mg/kg nebo 5.0 mg/kg stimulovalo u potkanů signifikantně lokomoci, avšak po opakovaném podání se tento vliv snížil (nesignifikantně po nižší dávce a signifikantně po dávce vyšší). V obou skupinách se však objevilo stereotypní otírání čenichu (stereotypie jsou popsány také jako jeden z projevů senzitizace). V Experimentu 3 byl zaznamenán signifikantní stimulační efekt metamfetaminu v dávce 0.5 mg/kg po jeho prvním podání u potkanů, i po aplikaci osmé dávky.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.