Comparison of behavioural effects of amisulpride with selected antidepressants in the mouse model of social interactions

PISTOVČÁKOVÁ, Jana and Alexandra ŠULCOVÁ. Comparison of behavioural effects of amisulpride with selected antidepressants in the mouse model of social interactions. Homeostasis in Health and Diseases. Milano, Italy: CIANS Homeostasis, 2005, vol. 43, No 3, p. 148-150. ISSN 0960-7560.

Basic information

• Original name: Comparison of behavioural effects of amisulpride with selected antidepressants in the mouse model of social interactions
• Name in Czech: Srovnání behaviorálních účinků amisulpridu a vybraných antidepresiv v myším modelu sociálních interakcí
• Authors: PISTOVČÁKOVÁ, Jana (703 Slovakia) and Alexandra ŠULCOVÁ (203 Czech Republic, guarantor).
• Edition: Homeostasis in Health and Diseases, Milano, Italy, CIANS Homeostasis, 2005, 0960-7560.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Italy
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/05:00013996
• Organization unit: Faculty of Medicine
• Keywords in English: amisulpride; antidepressant; behaviour; agonistic interactions; social conflict; mice
• Tags: agonistic interactions, amisulpride, antidepressant, behaviour, mice, social conflict
• Tags: International impact, Reviewed

Abstract

The objective of this pre-clinical study was to ascertain behavioural effects of amisulpride in the model of agonistic interactions in mice and compare it with the effects of selected antidepressants in the same animal model. This model is principally based on the conspecific social conflict in male mice. In conclusion, unlike citalopram and valproate, amisulpride at the doses used did not produce antidepressant-like effects in this ethological model in mice, nor did it influence agonistic behaviour in the sense of anxiolytic effects.

Abstract (in Czech)

Cílem naší preklinické studie bylo srovnat behaviorální účinky amisulpridu a vybraných antidepresiv v modelu agonistických interakcí u myší. Tento model ja založen na vnitrodruhovém sociálním konfliktu u dospělých myších samců. Po amisulpridu, narozdíl od valproátu a citalopramu, jsme nezjistili žádné antidepresivní ani anxiolytické účinky v použitém etologickém modelu u myší.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.