PISTOVČÁKOVÁ, Jana, Aikaterina MAKATSORI, Miroslav DOSTÁLEK, Alexandra ŠULCOVÁ and Daniela JEŽOVÁ. Endocrine and immune changes following chronic treatment with tiagabine and amisulpride in the olfactory bulbectomized rat model of depression. European Neuropsychopharmacology. Amsterdam: Elsevier B.V./ECNP, 2005, vol. 15, No 1, p. S44-S44, 1 pp. ISSN 0924-977X.
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Basic information
Original name Endocrine and immune changes following chronic treatment with tiagabine and amisulpride in the olfactory bulbectomized rat model of depression
Name in Czech Endokrinní a imunitní zmny po chronickém podávání tiagabinu a amisulpridu v modelu deprese u potkan - po bilaterálním odntí bulbus olfactorius
Authors PISTOVČÁKOVÁ, Jana (703 Slovakia), Aikaterina MAKATSORI (300 Greece), Miroslav DOSTÁLEK (203 Czech Republic), Alexandra ŠULCOVÁ (203 Czech Republic, guarantor) and Daniela JEŽOVÁ (703 Slovakia).
Edition European Neuropsychopharmacology, Amsterdam, Elsevier B.V./ECNP, 2005, 0924-977X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.510
RIV identification code RIV/00216224:14110/05:00013997
Organization unit Faculty of Medicine
UT WoS 000227331900055
Keywords in English olfactory bulbectomy; depression; tiagabine; amisulpride; rat; animal model
Tags amisulpride, animal model, Depression, olfactory bulbectomy, rat, tiagabine
Tags International impact, Reviewed
Changed by Changed by: MUDr. Jana Pistovčáková, Ph.D., učo 18252. Changed: 23/6/2009 13:20.
Abstract
The purpose of the study was to test endocrine and immune effects of antiepileptic drug tiagabine (TGB) and atypical neuroleptic amisulpride (AMS) in the well established animal model of depression bilateral olfactory bulbectomy (OB) in rats. The tested drugs elicited changes that resemble those seen following chronic treatment with clinically used antidepressants. Thus, they support further the clinical reports that TGB and AMS in addition to their antiepileptic/antipsychotic efficacy respectively may possess also antidepressant activity.
Abstract (in Czech)
Cílem studií bylo testovat účinky antiepileptika tiagabinu a atypického neuroleptika amisulpridu na endokrinní a imunitní funkce v potkaním modelu bilaterální olfaktorické bulbektomie. Výsledky naznačují potenciální antidepresivní účinky testovaných látek.
Links
MSM 141100001, plan (intention)Name: Plasticita řídících systémů centrálního nervového systému a možnosti jejího ovlivnění
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