Endocrine and immune changes following chronic treatment with
tiagabine and amisulpride in the olfactory bulbectomized rat
model of depression

J 2005

Endocrine and immune changes following chronic treatment with tiagabine and amisulpride in the olfactory bulbectomized rat model of depression

PISTOVČÁKOVÁ, Jana, Aikaterina MAKATSORI, Miroslav DOSTÁLEK, Alexandra ŠULCOVÁ, Daniela JEŽOVÁ et. al.

Basic information

Original name

Endocrine and immune changes following chronic treatment with tiagabine and amisulpride in the olfactory bulbectomized rat model of depression

Name in Czech

Endokrinní a imunitní zmny po chronickém podávání tiagabinu a amisulpridu v modelu deprese u potkan - po bilaterálním odntí bulbus olfactorius

Authors

PISTOVČÁKOVÁ, Jana (703 Slovakia), Aikaterina MAKATSORI (300 Greece), Miroslav DOSTÁLEK (203 Czech Republic), Alexandra ŠULCOVÁ (203 Czech Republic, guarantor) and Daniela JEŽOVÁ (703 Slovakia)

Edition

European Neuropsychopharmacology, Amsterdam, Elsevier B.V./ECNP, 2005, 0924-977X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.510

RIV identification code

RIV/00216224:14110/05:00013997

Organization unit

Faculty of Medicine

UT WoS

000227331900055

Keywords in English

olfactory bulbectomy; depression; tiagabine; amisulpride; rat; animal model

Abstract

ORIG CZ

V originále

The purpose of the study was to test endocrine and immune effects of antiepileptic drug tiagabine (TGB) and atypical neuroleptic amisulpride (AMS) in the well established animal model of depression bilateral olfactory bulbectomy (OB) in rats. The tested drugs elicited changes that resemble those seen following chronic treatment with clinically used antidepressants. Thus, they support further the clinical reports that TGB and AMS in addition to their antiepileptic/antipsychotic efficacy respectively may possess also antidepressant activity.

In Czech

Cílem studií bylo testovat účinky antiepileptika tiagabinu a atypického neuroleptika amisulpridu na endokrinní a imunitní funkce v potkaním modelu bilaterální olfaktorické bulbektomie. Výsledky naznačují potenciální antidepresivní účinky testovaných látek.

Links

MSM 141100001, plan (intention)

Name: Plasticita řídících systémů centrálního nervového systému a možnosti jejího ovlivnění

Citovat

PISTOVČÁKOVÁ, Jana, Aikaterina MAKATSORI, Miroslav DOSTÁLEK, Alexandra ŠULCOVÁ and Daniela JEŽOVÁ. Endocrine and immune changes following chronic treatment with tiagabine and amisulpride in the olfactory bulbectomized rat model of depression. European Neuropsychopharmacology. Amsterdam: Elsevier B.V./ECNP, 2005, vol. 15, No 1, p. S44-S44, 1 pp. ISSN 0924-977X.

@article{581845,
   author = {Pistovčáková, Jana and Makatsori, Aikaterina and Dostálek, Miroslav and Šulcová, Alexandra and Ježová, Daniela},
   article_location = {Amsterdam},
   article_number = {1},
   keywords = {olfactory bulbectomy; depression; tiagabine; amisulpride; rat; animal model},
   language = {eng},
   issn = {0924-977X},
   journal = {European Neuropsychopharmacology},
   title = {Endocrine and immune changes following chronic treatment with tiagabine and amisulpride in the olfactory bulbectomized rat model of depression},
   volume = {15},
   year = {2005}
}

TY  - JOUR
ID  - 581845
AU  - Pistovčáková, Jana - Makatsori, Aikaterina - Dostálek, Miroslav - Šulcová, Alexandra - Ježová, Daniela
PY  - 2005
TI  - Endocrine and immune changes following chronic treatment with tiagabine and amisulpride in the olfactory bulbectomized rat model of depression
JF  - European Neuropsychopharmacology
VL  - 15
IS  - 1
SP  - S44-S44
EP  - S44-S44
PB  - Elsevier B.V./ECNP
SN  - 0924977X
KW  - olfactory bulbectomy
KW  - depression
KW  - tiagabine
KW  - amisulpride
KW  - rat
KW  - animal model
N2  - The purpose of the study was to test endocrine and immune effects of antiepileptic drug tiagabine (TGB) and atypical neuroleptic amisulpride (AMS) in the well established animal model of depression bilateral olfactory bulbectomy (OB) in rats. The tested drugs elicited changes that resemble those seen following chronic treatment with clinically used antidepressants. Thus, they support further the clinical reports that TGB and AMS in addition to their antiepileptic/antipsychotic efficacy respectively may possess also antidepressant activity.
ER  -

PISTOVČÁKOVÁ, Jana, Aikaterina MAKATSORI, Miroslav DOSTÁLEK, Alexandra ŠULCOVÁ and Daniela JEŽOVÁ. Endocrine and immune changes following chronic treatment with tiagabine and amisulpride in the olfactory bulbectomized rat model of depression. \textit{European Neuropsychopharmacology}. Amsterdam: Elsevier B.V./ECNP, 2005, vol.~15, No~1, p.~S44-S44, 1 pp. ISSN~0924-977X.

Detailed Information on Publication Record