DOSTÁLEK, Miroslav, Eva HADAŠOVÁ, Mariana HANESOVÁ, Jana PISTOVČÁKOVÁ, Alexandra ŠULCOVÁ, Jan JUŘICA, Josef TOMANDL and Igor LINHART. Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats. (Effect of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats.). Eur J Drug Metab Pharmacokinet. Switzerland,: Medicne et Hygiena, 2005, vol. 30, No 3, p. 195-201. ISSN 0378-7966. |
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@article{584841, author = {Dostálek, Miroslav and Hadašová, Eva and Hanesová, Mariana and Pistovčáková, Jana and Šulcová, Alexandra and Juřica, Jan and Tomandl, Josef and Linhart, Igor}, article_location = {Switzerland,}, article_number = {3}, keywords = {Midazolam; Methamphetamine; Cytochrome P-450; CYP3A1/2 isozyme}, language = {eng}, issn = {0378-7966}, journal = {Eur J Drug Metab Pharmacokinet}, title = {Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats.}, volume = {30}, year = {2005} }
TY - JOUR ID - 584841 AU - Dostálek, Miroslav - Hadašová, Eva - Hanesová, Mariana - Pistovčáková, Jana - Šulcová, Alexandra - Juřica, Jan - Tomandl, Josef - Linhart, Igor PY - 2005 TI - Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats. JF - Eur J Drug Metab Pharmacokinet VL - 30 IS - 3 SP - 195-201 EP - 195-201 PB - Medicne et Hygiena SN - 03787966 KW - Midazolam KW - Methamphetamine KW - Cytochrome P-450 KW - CYP3A1/2 isozyme N2 - Methamphetamine is the fourth most frequently cited drug of abuse on treatment centre admission records behind cocaine, heroin and marijuana. We investigated the effect of methamphetamine (10 mg/kg, i.p., once daily for six days) on the pharmacokinetics of midazolam a substrate for rat cytochrome P-450 3A. Animals received a single injection of midazolam (5 mg/kg) in tail vein 24 h after the last dose of methamphetamine and placebo. Validated HPLC method was used to quantify all compounds of interest. The elimination half-life (t1/2) and the area under the concentration-time curve of midazolam were significantly reduced by pretreatment with methamphetamine to 63.8 % and 66.3 of control value, respectively and the clearance of midazolam was significantly increased by methamphetamine pretreatment. The results showed that administration of methamphetamine significantly stimulated metabolic activity of CYP3A1/2. With regard to a high level of homology between human and rat CYP isoforms studied, the results may have clinical impact in pharmacotherapy of methamphetamine abusers. ER -
DOSTÁLEK, Miroslav, Eva HADAŠOVÁ, Mariana HANESOVÁ, Jana PISTOVČÁKOVÁ, Alexandra ŠULCOVÁ, Jan JUŘICA, Josef TOMANDL and Igor LINHART. Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats. (Effect of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats.). \textit{Eur J Drug Metab Pharmacokinet}. Switzerland,: Medicne et Hygiena, 2005, vol.~30, No~3, p.~195-201. ISSN~0378-7966.
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