DOSTÁLEK, Miroslav, Jana PISTOVČÁKOVÁ, Veronika MINAŘÍKOVÁ, Jan JUŘICA, Josef TOMANDL and Eva HADAŠOVÁ. Effect of acute and repeated administration of methamphetamine on the activity of CYP2D in isolated perfused rat liver. Acta Veterinaria Brno. Brno: VFU Brno, 2005, vol. 74, No 3, p. 339-345. ISSN 0001-7213.
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Basic information
Original name Effect of acute and repeated administration of methamphetamine on the activity of CYP2D in isolated perfused rat liver
Name in Czech Vliv akutního a opakovaného podávání metamfetaminu na aktivitu CYP2D na modelu izolovaných perfundovaných jater
Authors DOSTÁLEK, Miroslav (203 Czech Republic), Jana PISTOVČÁKOVÁ (703 Slovakia), Veronika MINAŘÍKOVÁ (203 Czech Republic), Jan JUŘICA (203 Czech Republic), Josef TOMANDL (203 Czech Republic) and Eva HADAŠOVÁ (203 Czech Republic, guarantor).
Edition Acta Veterinaria Brno, Brno, VFU Brno, 2005, 0001-7213.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.353
RIV identification code RIV/00216224:14110/05:00014068
Organization unit Faculty of Medicine
UT WoS 000232717000003
Keywords in English Methamphetamine; Dextromethorphan; CYP2D; Liver; isolated perfused; Rat
Tags CYP2D, dextromethorphan, Isolated perfused, Liver, methamphetamine, rat
Changed by Changed by: doc. RNDr. Josef Tomandl, Ph.D., učo 47. Changed: 24/6/2009 19:46.
Abstract
The aim of this study was to ascertain the influence of acute and repeated methamphetamine administration on metabolic activity of CYP2D2. The study was performed in the model of isolated perfused rat liver using dextromethorphan as a specific marker of CYP2D2 activity. Acute administration of methamphetamine (10, 20 or 40 mg/kg, i.p., once daily for two days) significantly increased dextrorphan O-formation in the isolated liver mediated by CYP2D2 at all investigated doses in the 120th min of liver perfusion. Repeated administration of methamphetamine (10, 20 or 40 mg/kg, i.p., once daily for six days) significantly stimulated dextromethorphan O-demethylation via CYP2D2 dose-dependently. Thus, an induction of CYP2D2 metabolic activity was proved in these experiments. With regard to a high level of homology between human and rat CYP isoform studied, the results may have clinical impact in pharmacotherapy of methamphetamine abusers.
Abstract (in Czech)
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Links
MSM 141100001, plan (intention)Name: Plasticita řídících systémů centrálního nervového systému a možnosti jejího ovlivnění
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