MALOŇ, Michal, Zdeněk TRÁVNÍČEK, Radek MAREK and Miroslav STRNAD. Synthesis, spectral study and cytotoxicity of platinum(II) complexes with 2,9-disubstituted-6-benzylaminopurines. Journal of Inorganic Biochemistry. Elsevier, 2005, vol. 99, No 11, p. 2127-2138. ISSN 0162-0134.
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Basic information
Original name Synthesis, spectral study and cytotoxicity of platinum(II) complexes with 2,9-disubstituted-6-benzylaminopurines
Name in Czech Syntéza, spektrální studie a cytotoxicita Pt(II) komplexů 2,9-disubstituovaných-6-benzylaminopurinů
Authors MALOŇ, Michal (203 Czech Republic), Zdeněk TRÁVNÍČEK (203 Czech Republic, guarantor), Radek MAREK (203 Czech Republic) and Miroslav STRNAD (203 Czech Republic).
Edition Journal of Inorganic Biochemistry, Elsevier, 2005, 0162-0134.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.423
RIV identification code RIV/00216224:14310/05:00031136
Organization unit Faculty of Science
UT WoS 000233322800005
Keywords in English Platinum(II)complexes; multinuclear NMR study; CDK inhibitors; roscovitine; in vitro cytotoxicity
Tags CDK inhibitors, in vitro cytotoxicity, multinuclear NMR study, Platinum(II)complexes, roscovitine
Changed by Changed by: prof. RNDr. Radek Marek, Ph.D., učo 381. Changed: 3/11/2005 10:05.
A series of platinum(II) complexes with 2,9-disubstituted-6-benzylaminopurines has been prepared. The complexes have the following composition: cis-[Pt(Boh)2Cl2] (1), cis-[Pt(Oc)2Cl2] (2), cis-[Pt(Ros)2Cl2] (3), cis-[Pt(i-PrOc)2Cl2] (4), cis-[Pt(BohH+)2Cl2]Cl2 (5), cis-[Pt(OcH+)2Cl2]Cl2 (6), cis-[Pt(RosH+)2Cl2]Cl2 (7) and cis-[Pt(i-PrOcH+)2Cl2]Cl2 (8), where Boh = 2-(3-hydroxypropylamino)-6-benzylamino-9-isopropylpurine, Oc = 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine, Ros = 2-(R)-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine and i-PrOc = 2-(2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine. The complexes have been characterized by elemental analyses, conductivity measurements and their infrared, ES + mass (electrospray mass spectra in the positive ion mode) and NMR (1H, 13C, 15N and 195Pt) spectra. The results obtained from the physical studies, particularly from multinuclear NMR spectroscopy, show that in all the investigated complexes (18), two molecules of purine derivative are coordinated to platinum via the N(7) atom of the imidazole ring in a cis-configuration. The prepared compounds have been screened for their in vitro cytotoxicity against G-361 (human malignant melanoma), HOS (human osteogenic sarcoma), K-562 (human chronic myelogenous leukemia) and MCF-7 (human breast adenocarcinoma) cell lines. All complexes are significantly more active than the initial 2,9-disubstituted-6-benzylaminopurine derivatives. In the case of some tumour cell lines, IC50 values for the complexes (1, 3, 4, 5, 8) are significantly lower than those obtained for cisplatin and oxaliplatin. The best cytotoxicity was achieved for the complex (3) for which IC50 values range from 1 to 2 M.
Abstract (in Czech)
Byla připravena série Pt(II) komplexů 2,9-disubstituovaných-6-benzylaminopurinů, charakterizována pomocí spektroskopických metod a byla testována jejich cytotoxicita.
MSM0021622413, plan (intention)Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment
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