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@inproceedings{586162,
author = {Fiala, Radovan and Sklenář, Vladimír},
address = {Veldhoven},
booktitle = {EUROMAR/EENC 2005},
edition = {1},
keywords = {NMR spectroscopy; direct carbon detection; nucleic acid},
language = {eng},
location = {Veldhoven},
pages = {388-388},
publisher = {Utrecht University},
title = {13C-Detected Experiments for NMR Spectroscopy of Nucleic Acids},
year = {2005}
}
TY - JOUR
ID - 586162
AU - Fiala, Radovan - Sklenář, Vladimír
PY - 2005
TI - 13C-Detected Experiments for NMR Spectroscopy of Nucleic Acids
PB - Utrecht University
CY - Veldhoven
KW - NMR spectroscopy
KW - direct carbon detection
KW - nucleic acid
N2 - Nucleic acid bases contain a number of carbon atoms without directly attached protons. These include carbonyl groups in cytosine, thymine, uracil, and guanine, the C4 atom in cytosine, C5 in thymine, C4, C5, C6 in adenine, and C2, C4, and C5 in guanine. The direct detection of these carbon atoms offers an alternative method for obtaining their chemical shift values and/or data for investigation of the dynamics of nucleic acid bases. Furthermore, the chemical shifts of the amino nitrogen atoms whose protons are broadened beyond detection due to the exchange with water can be obtained using a 13C-detected 13C-15N correlation experiment. In the sugar moiety, the carbon detected experiments are suitable for obtaining 1H-13C correlations in the cases where the proton signal is obscured by the large water peak.
ER -
FIALA, Radovan and Vladimír SKLENÁŘ. 13C-Detected Experiments for NMR Spectroscopy of Nucleic Acids. In \textit{EUROMAR/EENC 2005}. 1st ed. Veldhoven: Utrecht University, 2005, p.~388-388.
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