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@inproceedings{587928,
author = {Etchin, Julia and Filippo, San Joe and Sung, Patrick and Krejci, Lumir},
address = {Switzerland},
booktitle = {Seventeenth Annual Fanconi Anemia Scientific Symposium},
keywords = {BRCA2 protein; recombination; DNA repair; instability},
language = {eng},
location = {Switzerland},
publisher = {Fanconi Anemia, RESEARCH FUND, INC.},
title = {Role of BRCA2/FANCD1 in Homologous Recombination},
url = {http://www.fanconi.org/research/Symposium/17thAnnual.htm},
year = {2005}
}
TY - JOUR
ID - 587928
AU - Etchin, Julia - Filippo, San Joe - Sung, Patrick - Krejci, Lumir
PY - 2005
TI - Role of BRCA2/FANCD1 in Homologous Recombination
PB - Fanconi Anemia, RESEARCH FUND, INC.
CY - Switzerland
KW - BRCA2 protein
KW - recombination
KW - DNA repair
KW - instability
UR - http://www.fanconi.org/research/Symposium/17thAnnual.htm
L2 - http://www.fanconi.org/research/Symposium/17thAnnual.htm
N2 - The molecular function of BRCA2 in homologous recombination has not been elucidated. We are using biochemical approaches as well as electron microscopy to validate the hypothesis that BRCA2 influences Rad51 recombinase activity by nucleating Rad51 onto ssDNA to promote the assembly of the Rad51 presynaptic filament, a pivotal intermediate in HR reactions. In addition, we have characterizaed the DNA binding properties of BRCA2-DBD fragment and examined variants of BRCA2 containing combinations of the Rad51-interaction and DNA binding motifs for the ability to target Rad51 to recombination substrates. By deciphering the functional significance of these interactions, we will be able to rationalize how mutations in BRCA2 lead to genome instability and breast cancer.
ER -
ETCHIN, Julia, San Joe FILIPPO, Patrick SUNG and Lumir KREJCI. Role of BRCA2/FANCD1 in Homologous Recombination. In \textit{Seventeenth Annual Fanconi Anemia Scientific Symposium}. Switzerland: Fanconi Anemia, RESEARCH FUND, INC., 2005, 45 pp.
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