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@inproceedings{588622,
author = {Krejci, Lumir and Plate, Iben and Sung, Patrick and Sehorn, Michael and Bussen, Wendy and Mortensen, Uffe H.},
address = {Bratislava, Slovakia},
booktitle = {XXIIth International Conference on Yeast Genetics and Molecular Biology},
keywords = {Recombination; DNA repair; Rad52; mediator; yeast},
language = {eng},
location = {Bratislava, Slovakia},
publisher = {ASM Conferences Program},
title = {New insight into mediator function of yeast Rad52 protein},
url = {http://www.yeast2005.org/},
year = {2005}
}
TY - JOUR
ID - 588622
AU - Krejci, Lumir - Plate, Iben - Sung, Patrick - Sehorn, Michael - Bussen, Wendy - Mortensen, Uffe H.
PY - 2005
TI - New insight into mediator function of yeast Rad52 protein
PB - ASM Conferences Program
CY - Bratislava, Slovakia
KW - Recombination
KW - DNA repair
KW - Rad52
KW - mediator
KW - yeast
UR - http://www.yeast2005.org/
L2 - http://www.yeast2005.org/
N2 - Homologous recombination (HR) represents an important means for the repair of chromosome breaks induced by exogenous agents (e.g. ionizing radiation) or that arise endogenously (e.g. replication of a damaged DNA template). The elimination of these breaks is critical for the maintenance of genome stability. DNA strand break repair by HR is mediated by genes of the RAD52 epistasis group, whose structure and function are highly conserved among eukaryotes. Rad52 protein plays central role in this process. It binds and anneals complemtary ssDNA, self-associate to form multimeric rings, interacts with Rad51, and promotes nucleation of Rad51 onto ssDNA. Here, we show that Rad52 contains second DNA binding domain that is capable of mediating Rad51-catalyzed strand exchange reaction. The molecular mechanism of Rad52 function in homologous recombination is disccused.
ER -
KREJCI, Lumir, Iben PLATE, Patrick SUNG, Michael SEHORN, Wendy BUSSEN and Uffe H. MORTENSEN. New insight into mediator function of yeast Rad52 protein. In \textit{XXIIth International Conference on Yeast Genetics and Molecular Biology}. Bratislava, Slovakia: ASM Conferences Program, 2005, 90 pp.
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