Detailed Information on Publication Record
2005
New insight into mediator function of yeast Rad52 protein
KREJCI, Lumir, Iben PLATE, Patrick SUNG, Michael SEHORN, Wendy BUSSEN et. al.Basic information
Original name
New insight into mediator function of yeast Rad52 protein
Name in Czech
Nový pohled na mediátorovou funkci proteinu Rad52
Authors
KREJCI, Lumir, Iben PLATE, Patrick SUNG, Michael SEHORN, Wendy BUSSEN and Uffe H. MORTENSEN
Edition
Bratislava, Slovakia, XXIIth International Conference on Yeast Genetics and Molecular Biology, 90 pp. 2005
Publisher
ASM Conferences Program
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
10600 1.6 Biological sciences
Country of publisher
Slovakia
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Organization unit
Faculty of Science
Keywords in English
Recombination; DNA repair; Rad52; mediator; yeast
Tags
Změněno: 30/6/2009 22:56, doc. Mgr. Lumír Krejčí, Ph.D.
V originále
Homologous recombination (HR) represents an important means for the repair of chromosome breaks induced by exogenous agents (e.g. ionizing radiation) or that arise endogenously (e.g. replication of a damaged DNA template). The elimination of these breaks is critical for the maintenance of genome stability. DNA strand break repair by HR is mediated by genes of the RAD52 epistasis group, whose structure and function are highly conserved among eukaryotes. Rad52 protein plays central role in this process. It binds and anneals complemtary ssDNA, self-associate to form multimeric rings, interacts with Rad51, and promotes nucleation of Rad51 onto ssDNA. Here, we show that Rad52 contains second DNA binding domain that is capable of mediating Rad51-catalyzed strand exchange reaction. The molecular mechanism of Rad52 function in homologous recombination is disccused.
In Czech
V této praci prezentujeme, že Rad52 protein obsahuje druhou DNA vazebnou doménu, která je schopna zprostredkovat Rad51-katalyzovanou výměnu řetězců. Diskutujeme molekulární mechanismus homologní rekombinace.
Links
MSM0021622413, plan (intention) |
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