Detailed Information on Publication Record
2005
The relationship between the carotid intima-media thickness, baroreflex sensitivity, variability in blood pressure and heart rate, and ejection fraction in normotensives and hypertensives
LÁBROVÁ, Růžena, Nataša HONZÍKOVÁ, Bohumil FIŠER, Eva MADĚROVÁ, Petra VYSOČANOVÁ et. al.Basic information
Original name
The relationship between the carotid intima-media thickness, baroreflex sensitivity, variability in blood pressure and heart rate, and ejection fraction in normotensives and hypertensives
Name in Czech
VZTAH MEZI TLOUŠŤKOU STĚNY A.CAROTIS, CITLIVOSTÍ BAROREFLEXU, VARIABILITOU V KREVNÍM TLAKU A SRDEČNÍ FREKVENCI A EJEKČNÍ FRAKCÍ U NORMOTONIKŮ A HYPERTONIKŮ
Name (in English)
The relationship between the carotid intima-media thickness, baroreflex sensitivity, variability in blood pressure and heart rate, and ejection fraction in normotensives and hypertensives
Authors
LÁBROVÁ, Růžena (203 Czech Republic, guarantor), Nataša HONZÍKOVÁ (203 Czech Republic), Bohumil FIŠER (203 Czech Republic), Eva MADĚROVÁ (203 Czech Republic), Petra VYSOČANOVÁ (203 Czech Republic), Zuzana NOVÁKOVÁ (203 Czech Republic), Miroslav JÍRA (203 Czech Republic) and Bořivoj SEMRÁD (203 Czech Republic)
Edition
Scripta medica, Brno, LF MU Brno, 2005, 1211-3395
Other information
Language
Czech
Type of outcome
Článek v odborném periodiku
Field of Study
30105 Physiology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/05:00014205
Organization unit
Faculty of Medicine
Keywords (in Czech)
Tloušťka intima-media, Baroreflex
Keywords in English
Carotid intima-media thickness; Baroreflex sensitivity; Heart rate variability; Blood pressure variability
Tags
Změněno: 19/6/2009 11:59, prof. MUDr. Bohumil Fišer, CSc.
V originále
A complex analysis of relationship between carotid intima-media thickness (IMT) and baroreflex sensitivity was performed in normotensives and hypertensives with respect to the signs of tonic and reflex autonomic control of heart rate and blood pressure (BP). The hierarchical multiple regression analysis by means of the forward selection of regressors proved an additive positive effect of age and BMI on a development of IMT in normotensives, but the influence of mean BP was insignificant . The same analysis performed in hypertensives showed, that their thick IMT is not further influenced neither by age nor by BMI nor by mean BP. Taking all subjects together, the dependence of IMT on age and mean BP from 24-h recordings was shown. Correlation of IMT with BRS and BRSf confirmed the hypothesis that the thickened carotid wall has lower compliance and therefore baroreflex sensitivity is lower. IMT correlates with many indices, but the increase of IMT in healthy subjects is dependent on age and BMI. BP plays a role besides age in thickening of carotid wall during the development of hypertension. It is probable that therapy in hypertonics decreases only sympathetic activation, but decreased BRS which is a risk factor for sudden cardiac death after myocardial infarction is not influenced by therapy.
In English
A complex analysis of relationship between carotid intima-media thickness (IMT) and baroreflex sensitivity was performed in normotensives and hypertensives with respect to the signs of tonic and reflex autonomic control of heart rate and blood pressure (BP).The hierarchical multiple regression analysis by means of the forward selection of regressors proved an additive positive effect of age and BMI on a development of IMT in normotensives, but the influence of mean BP was insignificant . The same analysis performed in hypertensives showed, that their thick IMT is not further influenced neither by age nor by BMI nor by mean BP. Taking all subjects together, the dependence of IMT on age and mean BP from 24-h recordings was shown. Correlation of IMT with BRS and BRSf confirmed the hypothesis that the thickened carotid wall has lower compliance and therefore baroreflex sensitivity is lower. IMT correlates with many indices, but the increase of IMT in healthy subjects is dependent on age and BMI. BP plays a role besides age in thickening of carotid wall during the development of hypertension. It is probable that therapy in hypertonics decreases only sympathetic activation, but decreased BRS which is a risk factor for sudden cardiac death after myocardial infarction is not influenced by therapy.
Links
| MSM0021622402, plan (intention) |
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| NA7362, research and development project |
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