| IZAKOVIČOVÁ HOLLÁ, Lydie, Kateřina KAŇKOVÁ and Anna VAŠKŮ. Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma. Clinical Biochemistry. ELSEVIER, 2006, vol. 39, No 3, p. 299-302. ISSN 0009-9120. |
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@article{591964,
author = {Izakovičová Hollá, Lydie and Kaňková, Kateřina and Vašků, Anna},
article_number = {3},
keywords = {gene polymorphism asthma MnSOD superoxide dismutase},
language = {eng},
issn = {0009-9120},
journal = {Clinical Biochemistry},
title = {Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma},
volume = {39},
year = {2006}
}
TY - JOUR
ID - 591964
AU - Izakovičová Hollá, Lydie - Kaňková, Kateřina - Vašků, Anna
PY - 2006
TI - Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma
JF - Clinical Biochemistry
VL - 39
IS - 3
SP - 299-302
EP - 299-302
PB - ELSEVIER
SN - 00099120
KW - gene polymorphism asthma MnSOD superoxide dismutase
N2 - We investigated the possible association between functional variant Ala-9Val in the MnSOD gene and asthma in the case-control study comprising 626 Caucasian subjects. MnSOD genotypes were determined by PCR with subsequent restriction analysis by BsaWI enzyme. Significant differences in allele frequencies between groups were not ascertained. Pursuant theses results, Ala-9Val polymorphism does not seem to be a significant predisposing factor for the bronchial asthma in the Czech population. All the same, indications that polymorphism in the MnSOD might modulate severity of disease in predisposed subjects certainly deserve additional attention and exploration.
ER -
IZAKOVIČOVÁ HOLLÁ, Lydie, Kateřina KAŇKOVÁ and Anna VAŠKŮ. Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma. \textit{Clinical Biochemistry}. ELSEVIER, 2006, vol.~39, No~3, p.~299-302. ISSN~0009-9120.
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