Extracellular diffusion parameters during and after unilateral carotid occlusion in rat

ŠLAIS, Karel, Aleš HOMOLA and Eva SYKOVÁ. Extracellular diffusion parameters during and after unilateral carotid occlusion in rat. In Sborník abstrakt 5. konference České neurovědecké společnosti. Praha: Czech Neuroscience Society, 2005, p. 81-81.

Basic information

• Original name: Extracellular diffusion parameters during and after unilateral carotid occlusion in rat
• Name in Czech: Extracelulární difúzní parametry v průběhu a po jednostranné okluzi karotid u potkanů
• Authors: ŠLAIS, Karel (203 Czech Republic, guarantor), Aleš HOMOLA (203 Czech Republic) and Eva SYKOVÁ (203 Czech Republic).
• Edition: Praha, Sborník abstrakt 5. konference České neurovědecké společnosti, p. 81-81, 1 pp. 2005.
• Publisher: Czech Neuroscience Society

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/05:00014234
• Organization unit: Faculty of Medicine
• Keywords in English: diffusion; ischemia; carotid occlusion; stroke
• Tags: carotid occlusion, Diffusion, ischemia, Stroke
• Tags: International impact

Abstract

Measurements of the ECS diffusion parameters in the brain have shown that a decreases and l increases during global cerebral ischemia, but there is a lack of information about the ECS parameters during hypoxia-ischemia and in the post-ischemic period after unilateral carotid occlusion. The observed post-ischemic increase in a and decrease in l suggest that extrasynaptic communication between neurons and glia is altered during the post-ischemic period. Moreover, the concentrations of neuroactive substances, metabolites and applied drugs may be altered and could play an important role in the recovery process from stroke.

Abstract (in Czech)

Práce studovala změny difúzních parametrů mozku v průběhu a po jednostranné okluzi karotid se současnou hypoxiií u potkanů. Byly prokázány změny extracelulárního prostoru a tortuozity jak v průběhu, tak v postischemické fázi experimentu.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.