The occurence of QTC prolongation in patients treated with psychopharmacs

ČEŠKOVÁ, Eva. The occurence of QTC prolongation in patients treated with psychopharmacs. In Book abstract XIII. Word congress of psychiatry. Cairo, Egypt: Egyptian Psychiatric association. s. 704-704. 2005.

Základní údaje

• Originální název: The occurence of QTC prolongation in patients treated with psychopharmacs
• Název česky: Výskyt prodloužení QTc intervalu u pacientů léčených psychofarmaky
• Název anglicky: The occurence of QTC prolongation in patients treated with psychopharmacs
• Autoři: ČEŠKOVÁ, Eva.
• Vydání: Cairo, Egypt, Book abstract XIII. Word congress of psychiatry, od s. 704-704, 1 s. 2005.
• Nakladatel: Egyptian Psychiatric association

Další údaje

• Originální jazyk: čeština
• Typ výsledku: Stať ve sborníku
• Obor: 30000 3. Medical and Health Sciences
• Stát vydavatele: Česká republika
• Utajení: není předmětem státního či obchodního tajemství
• Organizační jednotka: Lékařská fakulta
• Klíčová slova anglicky: the occurence of QTC; antipsychotics; prolongation
• Štítky: antipsychotics, prolongation, the occurence of QTC

Anotace

The QTc prolongation ant potentially fatal arrythmia may be induced by some psychotropic drugs. The aim of our project was to explore the occurence of QTc prolongation in psychiatric patients treated with a drug of known (or unexplored) proarrhytmic potential. Methods:the patient(male and female)hospitalised in the psychotic wards at the Department of Psychiatry treated with antipsychotics and antidepressants were included. A 12-lead ECG was recorded(sweep of 50 mm/s and voltage of 20 mm/mV), the QT interval was measured manually, corrected according to Bazett. QTc values of >0,46s in females were considered pathologic. Result: in 365 patients the total number of 457 ECGs were obtained. In 16 patients(4%) QTc prolongation was observed. Nevertheless, in none of them the QTc value exceeded 0,48 sec. Conclusions:The occurence of abnormal QTc was significantly lower than in available literature. Values associated with high risk of arrhythmias(QTc longer than 0.5 sec)were not observed. This could be connected with the change of spectrum of antipsychotics used, the general trend to use lower doses of antipsychotics and increasing awarennes about the long QT syndrome.

Anotace anglicky

The QTc prolongation ant potentially fatal arrythmia may be induced by some psychotropic drugs. The aim of our project was to explore the occurence of QTc prolongation in psychiatric patients treated with a drug of known (or unexplored) proarrhytmic potential. Methods:the patient(male and female)hospitalised in the psychotic wards at the Department of Psychiatry treated with antipsychotics and antidepressants were included. A 12-lead ECG was recorded(sweep of 50 mm/s and voltage of 20 mm/mV), the QT interval was measured manually, corrected according to Bazett. QTc values of >0,46s in females were considered pathologic. Result: in 365 patients the total number of 457 ECGs were obtained. In 16 patients(4%) QTc prolongation was observed. Nevertheless, in none of them the QTc value exceeded 0,48 sec. Conclusions:The occurence of abnormal QTc was significantly lower than in available literature. Values associated with high risk of arrhythmias(QTc longer than 0.5 sec)were not observed. This could be connected with the change of spectrum of antipsychotics used, the general trend to use lower doses of antipsychotics and increasing awarennes about the long QT syndrome.

Návaznosti

• NA7424, projekt VaV: Název: Molekulárně genetické aspekty proarytmického působení neantiarytmických preparátů

Investor: Ministerstvo zdravotnictví ČR, Molekulárně genetické aspekty proarytmického působení neantiarytmických preparátů

• NR8063, projekt VaV: Název: Mutační analýza kandidátních genů syndromu dlouhého QT intervalu.