THERMODYNAMIC AND KINETIC STUDIES OF LANTHANIDE(III) COMPLEXES WITH H5do3ap (1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC-10-(METHYLPHOSPHONIC ACID)), A MONOPHOSPHONATE ANALOGUE OF H4dota

TÁBORSKÝ, Petr, Přemysl LUBAL, Josef HAVEL, Jan KOTEK, Petr HERMANN and Ivan LUKEŠ. THERMODYNAMIC AND KINETIC STUDIES OF LANTHANIDE(III) COMPLEXES WITH H5do3ap (1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC-10-(METHYLPHOSPHONIC ACID)), A MONOPHOSPHONATE ANALOGUE OF H4dota. Collection of Czechoslovak Chemical Communications. Praha, 2005, vol. 70, No 11, p. 1909-1942. ISSN 0010-0765.

Basic information

• Original name: THERMODYNAMIC AND KINETIC STUDIES OF LANTHANIDE(III) COMPLEXES WITH H5do3ap (1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC-10-(METHYLPHOSPHONIC ACID)), A MONOPHOSPHONATE ANALOGUE OF H4dota
• Name in Czech: Termodynamická a kinetická studie komplexů lanthanoidů(III) s H5do3ap (1,4,7,10-tetraazacyklododekan-1,4,7-triaceto-10-(methylfosfonová kyselina)), monofosfonátovým analogem H4dota
• Authors: TÁBORSKÝ, Petr (203 Czech Republic), Přemysl LUBAL (203 Czech Republic, guarantor), Josef HAVEL (203 Czech Republic), Jan KOTEK (203 Czech Republic), Petr HERMANN (203 Czech Republic) and Ivan LUKEŠ (203 Czech Republic).
• Edition: Collection of Czechoslovak Chemical Communications, Praha, 2005, 0010-0765.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10406 Analytical chemistry
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: CCCC
• Impact factor: Impact factor: 0.949
• RIV identification code: RIV/00216224:14310/05:00012955
• Organization unit: Faculty of Science
• UT WoS: 000234236700012
• Keywords in English: Azacrown compounds; Phosphonate complexes; Macrocyclic ligand; Cyclen derivative; Tetraazacyclododecane; DOTA; Thermodynamics; Kinetics; Crystal structure determination;Potentiometry; Cerium; Gadolinium; Lanthanide cations.
• Tags: Azacrown compounds, cerium, Crystal structure determination, Cyclen derivative, DOTA, Gadolinium, kinetics, Lanthanide cations., macrocyclic ligand, phosphonate complexes, potentiometry, Tetraazacyclododecane, Thermodynamics

Abstract

Solution properties of complexes of a new H4dota-like ligand containing three acetate and one methylphosphonate pendant arms (H5do3ap, H5L) were studied. The ligand exhibits a high last dissociation constant (pKA = 13.83) as a consequence of the presence of phosphonate moiety. In solution, successive attachment of protons leads to several reorganizations of protonation sites and the neutral zwitterionic species H5do3ap has the same solution structure as in the solid state where the nitrogen atom binding methylphosphonate and the opposite nitrogen atoms are protonated. Stability constants with Na+ and trivalent lanthanide ions (La3+, Ce3+, Eu3+, Gd3+, Lu3+) and Y3+ were determined. The constants are comparable or higher than those of H4dota due to the higher overall basicity of H5do3ap. Formation of the stable protonated complexes as well as complexes with the L:M = 1:2 stoichiometry was proved. Formation and decomplexation kinetics of the Ce3+ and Gd3+ complexes were investigated.

Abstract (in Czech)

V předložené práci byly studovány vlastnosti komplexů kovů s ligandem, který je analogem H4dota obsahujícím tři acetátové a jedno methylfosfonové pendantní rameno. Bylo prokázáno, že poslední disociační konstanta je velmi vysoká (pKa=13,83)jako důsledek přítomnosti fosfonátového řetězce.

Links

• GA203/03/0168, research and development project: Name: Kineticky inertní komplexy iontů přechodných kovů a lanthanoidů. Design, syntéza a kinetická studia
• OC D18.001, research and development project: Name: Luminiscenční komplexy lanthanoidů pro analytické a diagnostické aplikace.