Detailed Information on Publication Record
2006
Polymorphism of DRD2 gene and ADHD
ŠERÝ, Omar, Ivana DRTÍLKOVÁ, Pavel THEINER, Renáta PITELOVÁ, Radim ŠTAIF et. al.Basic information
Original name
Polymorphism of DRD2 gene and ADHD
Name in Czech
Polymorfizmum genu pro DRD2 a ADHD
Name (in English)
Polymorphism of DRD2 gene and ADHD
Authors
ŠERÝ, Omar (203 Czech Republic, guarantor), Ivana DRTÍLKOVÁ (203 Czech Republic), Pavel THEINER (203 Czech Republic), Renáta PITELOVÁ (203 Czech Republic), Radim ŠTAIF (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Jan LOCHMAN (203 Czech Republic)
Edition
Neuroendocrinology Letters, Sweden, Stockholm, Maghira and Maas Publications, 2006, 0172-780X
Other information
Language
Czech
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.924
RIV identification code
RIV/00216224:14310/06:00016583
Organization unit
Faculty of Science
UT WoS
000238667700040
Keywords in English
ADHD; dopamine; DRD2; polymorphism; association; gene
Tags
Tags
International impact, Reviewed
Změněno: 13/2/2008 17:32, prof. RNDr. Omar Šerý, Ph.D.
V originále
Objectives: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. Design: We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. Setting: For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. Results: We found statistically different genotypic and allelic frequencies (p < 0,008, p < 0,002, respectively) of DRD2 polymorphism between two studied groups of boys. Main findings: According to our results we suppose that polymorphism TaqI A of DRD2 gene is involved in the pathogenesis of childhood ADHD in male subjects. Allele A1 and genotype A1A1 in male subjects is associated with ADHD. Conclusions: Our study confirmed the relationship between TaqI A polymorphism of DRD2 gene and ADHD published previously.
In English
Objectives: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. Design: We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. Setting: For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. Results: We found statistically different genotypic and allelic frequencies (p < 0,008, p < 0,002, respectively) of DRD2 polymorphism between two studied groups of boys. Main findings: According to our results we suppose that polymorphism TaqI A of DRD2 gene is involved in the pathogenesis of childhood ADHD in male subjects. Allele A1 and genotype A1A1 in male subjects is associated with ADHD. Conclusions: Our study confirmed the relationship between TaqI A polymorphism of DRD2 gene and ADHD published previously.
Links
| MSM0021622413, plan (intention) |
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| NF6520, research and development project |
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