Detailed Information on Publication Record
2005
Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ, Jiří ŠIMURDA et. al.Basic information
Original name
Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes
Name in Czech
Vliv ajmalinu na akcni napeti a iontove proudy u komorovych srdecnich bunek potkana
Authors
BÉBAROVÁ, Markéta (203 Czech Republic, guarantor), Peter MATEJOVIČ (703 Slovakia), Michal PÁSEK (203 Czech Republic), Milena ŠIMURDOVÁ (203 Czech Republic) and Jiří ŠIMURDA (203 Czech Republic)
Edition
General Physiology and Biophysics, 2005, 0231-5882
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30105 Physiology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.560
RIV identification code
RIV/00216224:14110/05:00014397
Organization unit
Faculty of Medicine
UT WoS
000233582900004
Keywords in English
ajmaline; action potential; ionic currents; concentration dependence; rat ventricular myocytes
Tags
International impact, Reviewed
Změněno: 12/6/2009 15:14, doc. MUDr. Markéta Bébarová, Ph.D.
V originále
Ajmaline decreased the upstroke velocity of action potential and action potential amplitude, increased the action potential duration measured at 50 and 90% repolarization, and reversibly inhibited most components of membrane ionic current in a concentration-dependent manner; IC50 was 27.8 umol/l for INa, 70.8 umol/l for ICa, 25.9 umol/l for Ito, 61.0 umol/l for IK, and 13.3 umol/l for IKATP.
In Czech
Ajmalin snizoval rychlost depolarizace akcniho napeti a amplitudu akcniho napeti, prodluzoval trvani akcniho napeti merene na urovni 50 a 90% repolarizace a reverzibilne inhiboval hlavni komponenty iontoveho membranoveho proudu v zavislosti na aplikovane koncentraci; IC50 byla 27.8 umol/l pro INa, 70.8 umol/l pro ICa, 25.9 umol/l pro Ito, 61.0 umol/l pro IK a 13.3 umol/l pro IKATP.
Links
| MSM0021622402, plan (intention) |
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