BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes. General Physiology and Biophysics. 2005, vol. 24, No 3, p. 311-325. ISSN 0231-5882.
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Basic information
Original name Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes
Name in Czech Vliv ajmalinu na akcni napeti a iontove proudy u komorovych srdecnich bunek potkana
Authors BÉBAROVÁ, Markéta (203 Czech Republic, guarantor), Peter MATEJOVIČ (703 Slovakia), Michal PÁSEK (203 Czech Republic), Milena ŠIMURDOVÁ (203 Czech Republic) and Jiří ŠIMURDA (203 Czech Republic).
Edition General Physiology and Biophysics, 2005, 0231-5882.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.560
RIV identification code RIV/00216224:14110/05:00014397
Organization unit Faculty of Medicine
UT WoS 000233582900004
Keywords in English ajmaline; action potential; ionic currents; concentration dependence; rat ventricular myocytes
Tags Action potential, ajmaline, concentration dependence, ionic currents, rat ventricular myocytes
Tags International impact, Reviewed
Changed by Changed by: doc. MUDr. Markéta Bébarová, Ph.D., učo 15000. Changed: 12/6/2009 15:14.
Abstract
Ajmaline decreased the upstroke velocity of action potential and action potential amplitude, increased the action potential duration measured at 50 and 90% repolarization, and reversibly inhibited most components of membrane ionic current in a concentration-dependent manner; IC50 was 27.8 umol/l for INa, 70.8 umol/l for ICa, 25.9 umol/l for Ito, 61.0 umol/l for IK, and 13.3 umol/l for IKATP.
Abstract (in Czech)
Ajmalin snizoval rychlost depolarizace akcniho napeti a amplitudu akcniho napeti, prodluzoval trvani akcniho napeti merene na urovni 50 a 90% repolarizace a reverzibilne inhiboval hlavni komponenty iontoveho membranoveho proudu v zavislosti na aplikovane koncentraci; IC50 byla 27.8 umol/l pro INa, 70.8 umol/l pro ICa, 25.9 umol/l pro Ito, 61.0 umol/l pro IK a 13.3 umol/l pro IKATP.
Links
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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