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@article{600809,
author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Šimurdová, Milena and Šimurda, Jiří},
article_number = {3},
keywords = {ajmaline; action potential; ionic currents; concentration dependence; rat ventricular myocytes},
language = {eng},
issn = {0231-5882},
journal = {General Physiology and Biophysics},
title = {Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes},
volume = {24},
year = {2005}
}
TY - JOUR
ID - 600809
AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Šimurdová, Milena - Šimurda, Jiří
PY - 2005
TI - Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes
JF - General Physiology and Biophysics
VL - 24
IS - 3
SP - 311-325
EP - 311-325
SN - 02315882
KW - ajmaline
KW - action potential
KW - ionic currents
KW - concentration dependence
KW - rat ventricular myocytes
N2 - Ajmaline decreased the upstroke velocity of action potential and action potential amplitude, increased the action potential duration measured at 50 and 90% repolarization, and reversibly inhibited most components of membrane ionic current in a concentration-dependent manner; IC50 was 27.8 umol/l for INa, 70.8 umol/l for ICa, 25.9 umol/l for Ito, 61.0 umol/l for IK, and 13.3 umol/l for IKATP.
ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes. \textit{General Physiology and Biophysics}. roč.~24, č.~3, s.~311-325. ISSN~0231-5882. 2005.
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