The expression of cannabinoid receptor type 2 in the dorsal root ganglia in rats after peripheral nerve injury

SVÍŽENSKÁ, Ivana, Ilona KLUSÁKOVÁ and Petr DUBOVÝ. The expression of cannabinoid receptor type 2 in the dorsal root ganglia in rats after peripheral nerve injury. In Programme and Abstract Book of the 43rd Congress of the Czech Anatomical Society and 42nd Lojda Symposium "Progress in Basic, Applied and Diagnostic Histochemistry", Brno, Czech Republic, September 4-7, 2005. 2005. ISBN 80-210-3793-8.

Basic information

• Original name: The expression of cannabinoid receptor type 2 in the dorsal root ganglia in rats after peripheral nerve injury
• Name in Czech: Exprese CB2 ve spinálních gangliích laboratorního potkana po poškození periferního nervu
• Authors: SVÍŽENSKÁ, Ivana, Ilona KLUSÁKOVÁ and Petr DUBOVÝ.
• Edition: Programme and Abstract Book of the 43rd Congress of the Czech Anatomical Society and 42nd Lojda Symposium "Progress in Basic, Applied and Diagnostic Histochemistry", Brno, Czech Republic, September 4-7, 2005, 2005.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• ISBN: 80-210-3793-8
• Keywords in English: cannabinoid; peripheral nervous system; rat; dorsal root ganglia
• Tags: cannabinoid, Dorsal root ganglia, peripheral nervous system, rat

Abstract

Cannabinoid compounds have been shown to produce antinociception and antihyperalgesia by acting upon cannabinoid receptors (CB)located in both the CNS and periphery. A potential mechanism by which cannabinoids could inhibit nociception in the periphery is the activation of cannabinoid receptors located on the primary nociceptive neurons. Cannabinoid receptor type 2 (CB2)- selective agonists do not produce centrally mediated effects typical of cannabinoids retaining agonist activity at the CB1 receptor. Thus they may have promise for the treatment of pain and inflammation without CNS side effects. In the present study we evaluated the immunohistochemical distribution of CB2 in the intact dorsal root ganglia (DRG) of the adult rat and its changes in the rat neuropathic pain model.

Abstract (in Czech)

Kanabinoidy způsobují antinocicepci a antihyperalgézii vazbou na kanabinoidní receptory (CB) v CNS i periférii. Jedním z možných mechanizmů inhibice nocicepce v periférii je aktivace CB lokalizovaných na primárních senzorických neuronech. Selektivní agonisté kanabinoidních receptorů typu 2 (CB2) nezpůsobují centrální účinky typické pro kanabinoidy aktivující CB1. Proto představují naději pro léčbu bolesti a zánětu bez vyvolání vedlejších efektů v CNS. Studie předkládá výsledky imunohistochemické exprese CB2 v intaktních spinálních gangliích dospělého laboratorního potkana a a její změny u některých modelů neuropatické bolesti.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.