Action potential voltage clamp analysis of rate-dependent changes of action potential in rat ventricular myocytes

BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Action potential voltage clamp analysis of rate-dependent changes of action potential in rat ventricular myocytes. In Physiological Research. 2005. ISSN 0862-8408.

Basic information

• Original name: Action potential voltage clamp analysis of rate-dependent changes of action potential in rat ventricular myocytes
• Name in Czech: Analyza frekvecne zavislych zmen akcniho napeti u komorovych srdecnich bunek potkana metodou vnuceneho akcniho napeti
• Authors: BÉBAROVÁ, Markéta (203 Czech Republic, guarantor, belonging to the institution), Peter MATEJOVIČ (703 Slovakia, belonging to the institution), Michal PÁSEK (203 Czech Republic, belonging to the institution), Milena ŠIMURDOVÁ (203 Czech Republic, belonging to the institution) and Jiří ŠIMURDA (203 Czech Republic, belonging to the institution).
• Edition: Physiological Research, 2005.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30105 Physiology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.806
• RIV identification code: RIV/00216224:14110/05:00013081
• Organization unit: Faculty of Medicine
• ISSN: 0862-8408
• Keywords in English: action potential; AP clamp; rate dependence; rat
• Tags: Action potential, AP clamp, rat, rate dependence
• Tags: International impact

Abstract

The main determinants of rate-dependent of action potential duration in rat ventricular myocytes are variations of the L-type calcium current ICa-L (gradual increase caused by modulatory effect of the Ca2+ transient) and the transient outward current Ito (decrease due to cumulative inactivation). These contemporary variations of ICa-L and Ito supported each other in the rate-dependent modulation of action potential prolongation. Under our experimental conditions, participation of other currents was negligible.

Abstract (in Czech)

Frekvencne zavisle prodluzovani akcniho napeti u komorovych srdecnich bunek potkana je dano postupnym vzestupen L-typu vapnikoveho proudu ICa-L (diky modulacnimu vlivu Ca2+ transientu) a poklesem prechodneho draslikoveho proudu z bunky Ito (diky kumulativni inaktivaci). Obe zmeny se vzajemne podporuji. Dalsi proudove slozky se na frekvencne zavisle regulace delky akcniho napeti v nasich experimentalnich podminkach neucastnily.

Links

• GA305/04/1385, research and development project: Name: Modulační úloha sigma signalizace na elektromechanické vztahy izolovaného kardiomyocytu a srdce

Investor: Czech Science Foundation, Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart

• MSM 141100004, plan (intention): Name: Časná diagnostika kardiovaskulárních chorob