a 2005

Action potential voltage clamp analysis of rate-dependent changes of action potential in rat ventricular myocytes

BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ, Jiří ŠIMURDA et. al.

Basic information

Original name

Action potential voltage clamp analysis of rate-dependent changes of action potential in rat ventricular myocytes

Name in Czech

Analyza frekvecne zavislych zmen akcniho napeti u komorovych srdecnich bunek potkana metodou vnuceneho akcniho napeti

Authors

BÉBAROVÁ, Markéta (203 Czech Republic, guarantor, belonging to the institution), Peter MATEJOVIČ (703 Slovakia, belonging to the institution), Michal PÁSEK (203 Czech Republic, belonging to the institution), Milena ŠIMURDOVÁ (203 Czech Republic, belonging to the institution) and Jiří ŠIMURDA (203 Czech Republic, belonging to the institution)

Edition

Physiological Research, 2005

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.806

RIV identification code

RIV/00216224:14110/05:00013081

Organization unit

Faculty of Medicine

ISSN

Keywords in English

action potential; AP clamp; rate dependence; rat

Tags

Tags

International impact
Změněno: 19/1/2013 21:50, doc. MUDr. Markéta Bébarová, Ph.D.

Abstract

ORIG CZ

V originále

The main determinants of rate-dependent of action potential duration in rat ventricular myocytes are variations of the L-type calcium current ICa-L (gradual increase caused by modulatory effect of the Ca2+ transient) and the transient outward current Ito (decrease due to cumulative inactivation). These contemporary variations of ICa-L and Ito supported each other in the rate-dependent modulation of action potential prolongation. Under our experimental conditions, participation of other currents was negligible.

In Czech

Frekvencne zavisle prodluzovani akcniho napeti u komorovych srdecnich bunek potkana je dano postupnym vzestupen L-typu vapnikoveho proudu ICa-L (diky modulacnimu vlivu Ca2+ transientu) a poklesem prechodneho draslikoveho proudu z bunky Ito (diky kumulativni inaktivaci). Obe zmeny se vzajemne podporuji. Dalsi proudove slozky se na frekvencne zavisle regulace delky akcniho napeti v nasich experimentalnich podminkach neucastnily.

Links

GA305/04/1385, research and development project
Name: Modulační úloha sigma signalizace na elektromechanické vztahy izolovaného kardiomyocytu a srdce
Investor: Czech Science Foundation, Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart
MSM 141100004, plan (intention)
Name: Časná diagnostika kardiovaskulárních chorob