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@article{609086, author = {Pacherník, J. and Bryja, V. and Ešner, M. and Dvořák, P. and Hampl, Aleš}, article_number = {2}, keywords = {cells}, language = {eng}, issn = {0862-8408}, journal = {Physiol. Res.}, title = {Retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells is potentiated by leukemia inhibitory factor}, volume = {54}, year = {2005} }
TY - JOUR ID - 609086 AU - Pacherník, J. - Bryja, V. - Ešner, M. - Dvořák, P. - Hampl, Aleš PY - 2005 TI - Retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells is potentiated by leukemia inhibitory factor JF - Physiol. Res. VL - 54 IS - 2 SP - 257-262 EP - 257-262 SN - 08628408 KW - cells N2 - Leukemia inhibitory factor (LIF) is a cytokine that exhibits proliferating, survival and differentiation activities in a wide range of cell types. Here we show that LIF potentiates retinoic acid-mediated neural induction in pluripotent P19 embryonal carcinoma cells. This activity of LIF was demonstrated by a profounded neural morphology followed by increased expression of neural-specific proteins (N-CAM, III beta-tubulin, and GAP-43), up-regulation of early neural lineage-specific gene Mash-1, and down-regulation of early endoderm-specific genes alfa-fetoprotein and GATA-4. Moreover, LIF also slows growth and increases the level of apoptosis in differentiating cells. ER -
PACHERNÍK, J., V. BRYJA, M. EŠNER, P. DVOŘÁK a Aleš HAMPL. Retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells is potentiated by leukemia inhibitory factor. \textit{Physiol. Res.}. 2005, roč.~54, č.~2, s.~257-262. ISSN~0862-8408.
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