| VONDRÁČEK, J., M. MACHALA, V. BRYJA, K. CHRAMOSTOVÁ, P. KRČMÁR, C. DIETRICH, Aleš HAMPL and Alois KOZUBÍK. Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells. Toxicological sciences. 2005, vol. 83, No 1, p. 53-63. ISSN 1096-6080. |
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@article{611524,
author = {Vondráček, J. and Machala, M. and Bryja, V. and Chramostová, K. and Krčmár, P. and Dietrich, C. and Hampl, Aleš and Kozubík, Alois},
article_number = {1},
keywords = {cells},
language = {eng},
issn = {1096-6080},
journal = {Toxicological sciences},
title = {Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells},
volume = {83},
year = {2005}
}
TY - JOUR
ID - 611524
AU - Vondráček, J. - Machala, M. - Bryja, V. - Chramostová, K. - Krčmár, P. - Dietrich, C. - Hampl, Aleš - Kozubík, Alois
PY - 2005
TI - Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells
JF - Toxicological sciences
VL - 83
IS - 1
SP - 53-63
EP - 53-63
SN - 10966080
KW - cells
N2 - Polychlorinated biphenyls (PCBs) are an important group of persistent environmental contaminants that exhibit tumor promoting effects in experimental animals. In this study, the effects of six model PCB congeners and hydroxylated PCB metabolites on proliferation of confluent rat liver epithelial stem-like WB-F344 cells were investigated. The data suggest that dioxin-like PCBs can release rat liver epithelial cells from contact inhibition and induce cell proliferation by increasing cyclin A protein levels, which then leads to upregulation of cyclin A/cdk2 activity and initiation of DNA replication. This mechanism could be involved in tumor promoting effects of dioxin-like PCBs.
ER -
VONDRÁČEK, J., M. MACHALA, V. BRYJA, K. CHRAMOSTOVÁ, P. KRČMÁR, C. DIETRICH, Aleš HAMPL and Alois KOZUBÍK. Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells. \textit{Toxicological sciences}. 2005, vol.~83, No~1, p.~53-63. ISSN~1096-6080.
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