Ecotoxicity and genotoxicity assessment of cytostatic
pharmaceuticals

D 2005

Ecotoxicity and genotoxicity assessment of cytostatic pharmaceuticals

ZOUNKOVÁ, Radka, Klára HILSCHEROVÁ, Pavel ODRÁŠKA, Tomáš BARTOŠ, Luděk BLÁHA et. al.

Basic information

Original name

Ecotoxicity and genotoxicity assessment of cytostatic pharmaceuticals

Name in Czech

Stanovení ekotoxicity a genotoxicity cytostatik

Authors

ZOUNKOVÁ, Radka (203 Czech Republic, guarantor), Klára HILSCHEROVÁ (203 Czech Republic), Pavel ODRÁŠKA (203 Czech Republic), Tomáš BARTOŠ (203 Czech Republic), Luděk BLÁHA (203 Czech Republic), Blahoslav MARŠÁLEK (203 Czech Republic) and Ivan HOLOUBEK (203 Czech Republic)

Edition

Lille, France, SETAC Europe 15th Annual Meeting, p. 126-127, 2005

Publisher

SETAC Europe

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30304 Public and environmental health

Country of publisher

France

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/05:00014598

Organization unit

Faculty of Science

UT WoS

000249528000025

Keywords in English

pharmaceuticals; environment; cytostatic; ecotoxicity; genotoxicty

Abstract

ORIG CZ

V originále

In recent years a great consideration is given to the issue of environmental contamination by pharmaceuticals, especially antibiotics and hormones. Less attention is given to other toxic compounds that may enter the environment, such as cytostatic (antineoplastic) agents. Pharmaceuticals (including cytostatics) might induce carcinogenic, mutagenic or teratogenic effects in non-target organisms, and are excreted into the the hospital or communal waste waters by patients in considerable amounts. In this contribution we present the assessment of ecotoxicity and genotoxicity of cytostatic agents selected with respect to high amounts used such as cyclophosphamide, 5-fluorouracil, cis-platin. Ecotoxicity was investigated with a series of bioassays (inhibition of Vibrio fisheri luminescence, immobilisation of Daphnia magna, growth inhibition of Raphidocelis subcapicata algae). Genotoxic potential was determined with SOS Chromotest bacterial bioassay. Our results provide first basic ecotoxicity data for serious evaluation of environmental risks of this class of highly toxic pharmaceuticals.

In Czech

Genotoxicita a ekotoxicita farmak

Links

MSM0021622412, plan (intention)

Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)

Citovat

ZOUNKOVÁ, Radka, Klára HILSCHEROVÁ, Pavel ODRÁŠKA, Tomáš BARTOŠ, Luděk BLÁHA, Blahoslav MARŠÁLEK and Ivan HOLOUBEK. Ecotoxicity and genotoxicity assessment of cytostatic pharmaceuticals. In SETAC Europe 15th Annual Meeting. Lille, France: SETAC Europe, 2005, p. 126-127.

@inproceedings{618473,
   author = {Zounková, Radka and Hilscherová, Klára and Odráška, Pavel and Bartoš, Tomáš and Bláha, Luděk and Maršálek, Blahoslav and Holoubek, Ivan},
   address = {Lille, France},
   booktitle = {SETAC Europe 15th Annual Meeting},
   keywords = {pharmaceuticals; environment; cytostatic; ecotoxicity; genotoxicty},
   language = {eng},
   location = {Lille, France},
   pages = {126-127},
   publisher = {SETAC Europe},
   title = {Ecotoxicity and genotoxicity assessment of cytostatic pharmaceuticals},
   year = {2005}
}

TY  - JOUR
ID  - 618473
AU  - Zounková, Radka - Hilscherová, Klára - Odráška, Pavel - Bartoš, Tomáš - Bláha, Luděk - Maršálek, Blahoslav - Holoubek, Ivan
PY  - 2005
TI  - Ecotoxicity and genotoxicity assessment of cytostatic pharmaceuticals
PB  - SETAC Europe
CY  - Lille, France
KW  - pharmaceuticals
KW  - environment
KW  - cytostatic
KW  - ecotoxicity
KW  - genotoxicty
N2  - In recent years a great consideration is given to the issue of environmental contamination by pharmaceuticals, especially antibiotics and hormones. Less attention is given to other toxic compounds that may enter the environment, such as cytostatic (antineoplastic) agents. Pharmaceuticals (including cytostatics) might induce carcinogenic, mutagenic or teratogenic effects in non-target organisms, and are excreted into the the hospital or communal waste waters by patients in considerable amounts. In this contribution we present the assessment of ecotoxicity and genotoxicity of cytostatic agents selected with respect to high amounts used such as cyclophosphamide, 5-fluorouracil, cis-platin. Ecotoxicity was investigated with a series of bioassays (inhibition of Vibrio fisheri luminescence, immobilisation of Daphnia magna, growth inhibition of Raphidocelis subcapicata algae). Genotoxic potential was determined with SOS Chromotest bacterial bioassay. Our results provide first basic ecotoxicity data for serious evaluation of environmental risks of this class of highly toxic pharmaceuticals.
ER  -

ZOUNKOVÁ, Radka, Klára HILSCHEROVÁ, Pavel ODRÁŠKA, Tomáš BARTOŠ, Luděk BLÁHA, Blahoslav MARŠÁLEK and Ivan HOLOUBEK. Ecotoxicity and genotoxicity assessment of cytostatic pharmaceuticals. In \textit{SETAC Europe 15th Annual Meeting}. Lille, France: SETAC Europe, 2005, p.~126-127.

Detailed Information on Publication Record