Comparison of the genomes of pathogenic treponemes, Treponema pallidum ssp. pallidum, ssp. pertenue and Treponema paraluiscuniculi.

ŠMAJS, David, Michal STROUHAL, Petra MATĚJKOVÁ, S.J. NORRIS and G.M. WEINSTOCK. Comparison of the genomes of pathogenic treponemes, Treponema pallidum ssp. pallidum, ssp. pertenue and Treponema paraluiscuniculi. In Clinical Microbiology and Infection. United Kingdom: Blackwell Publishing, 2005, p. 248. ISSN 1470-9465.

Basic information

Original name

Comparison of the genomes of pathogenic treponemes, Treponema pallidum ssp. pallidum, ssp. pertenue and Treponema paraluiscuniculi.

Name in Czech

Srovnání genomů patogenních treponem, Treponema pallidum ssp. pallidum, ssp. pertenue a Treponema paraluiscuniculi.

Authors

ŠMAJS, David (203 Czech Republic, guarantor), Michal STROUHAL (203 Czech Republic), Petra MATĚJKOVÁ (203 Czech Republic), S.J. NORRIS (840 United States of America) and G.M. WEINSTOCK (840 United States of America)

Edition

United Kingdom, Clinical Microbiology and Infection, p. 248-248, 2005

Publisher

Blackwell Publishing

---

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

Genetics and molecular biology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/05:00013191

Organization unit

Faculty of Medicine

ISSN

Keywords in English

Treponema pallidum ssp. pallidum; Treponema pallidum ssp. pertenue; Treponema paraluiscuniculi

Tags

Treponema pallidum ssp. pallidum, Treponema pallidum ssp. pertenue, Treponema paraluiscuniculi

Tags

International impact, Reviewed

---

Abstract

V originále

Objectives. Genomes of closely related treponemes, Treponema pallidum ssp. pallidum (strains Nichols and SS14) and Treponema pallidum ssp. pertenue (Gauthier, Samoan D) were compared with the genome of Treponema paraluiscuniculi using genomic techniques. T. pallidum ssp. pallidum is the causative agent of a highly invasive human disease syphilis, T. pallidum ssp. pertenue is the causative agent of yaws and T. paraluiscuniculi is not pathogenic to humans. After labelling of chromosomal DNA using random hexamers and hybridization to the DNA microarray, at least 15 T. paraluiscuniculi genes showed significantly lower signals when compared to signals of T. pallidum ssp. pallidum.

In Czech

Genomy blízce příbuzných treponem, Treponema pallidum ssp. pallidum (kmenů Nichols a SS14) a Treponema pallidum ssp. pertenue (Samoan D) byly porovnány s genomem Treponema paraluiscuniculi (kmenCuniculi A) s použitím technik komparativní genomiky. Po značení chromosomální DNA s použitím hexamerů o náhodné sekvenci a hybridizaci k DNA microarray bylo nalezeno nejméně 15 genů T. paraluiscuniculi se signifikantně nižším signálem oproti kmeni Nichols.

---

Links

GA310/04/0021, research and development project	Name: Postgenomické studie syfilitické spirochety Treponema pallidum Investor: Czech Science Foundation, Postgenomic studies on Treponema pallidum, the syphilis spirochete
MSM0021622415, plan (intention)	Name: Molekulární podstata buněčných a tkáňových regulací Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations
NI7351, research and development project	Name: Komparativní genomika patogenních spirochet rodu Treponema: cesta k sekvenčně specifické diagnostice Investor: Ministry of Health of the CR