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@proceedings{621661,
author = {Janalíková, Magda and Šmajs, David and Šmarda, Jan},
booktitle = {Supplement Abstracts of 12th European Conference on Bacterial Protein Toxins},
keywords = {colicin U; colicin Y; immunity protein},
language = {eng},
title = {Molecular recognition of colicin U and Y pore-forming domains by their cognate immunity proteins.},
year = {2005}
}
TY - CONF
ID - 621661
AU - Janalíková, Magda - Šmajs, David - Šmarda, Jan
PY - 2005
TI - Molecular recognition of colicin U and Y pore-forming domains by their cognate immunity proteins.
KW - colicin U
KW - colicin Y
KW - immunity protein
N2 - Colicin U is an antibacterial pore-forming toxin produced by Shigella boydii that kills sensitive bacterial strains of Escherichia coli and closely related organisms [1]. The colicin U transmembrane immunity protein [2] that is encoded on the pColU plasmid ensures that producer bacteria are protected against the colicin U lethal action. The colicin-immunity protein recognition is a suitable model for studying protein-protein interactions. More than 40 mutant colicins were prepared and their toxic effect was tested on the sensitive bacteria transformed with plasmid harboring either cui (colicin U immunity) gene or cyi (colicin Y immunity) gene. Colicin U variants with point mutations in the hydrophobic hairpin, F576Y and G580V, were significantly less recognized by Cui, in addition to colicin U with K609R mutation localized downstream of hydrophobic hairpin.
ER -
JANALÍKOVÁ, Magda, David ŠMAJS and Jan ŠMARDA. Molecular recognition of colicin U and Y pore-forming domains by their cognate immunity proteins. In \textit{Supplement Abstracts of 12th European Conference on Bacterial Protein Toxins}. 2005.
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