CHRISTÉ, Georges, L. RESTIER, M. CHAHINE, P. CHEVALIER and Michal PÁSEK. Effects of a persistent sodium current through mutated hNav1.5 sodium channels on intracellular ionic homeostasis in a ventricular cell model. In Computers in cardiology 2005. Lyon: IEEE, 2005, p. 997-1000. ISBN 0-7803-9337-6.
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Basic information
Original name Effects of a persistent sodium current through mutated hNav1.5 sodium channels on intracellular ionic homeostasis in a ventricular cell model
Name in Czech Účinek persistentního sodíkového proudu přes mutované hNav1.5 sodíkové kanály na intracelulární iontovou rovnováhu v modelu komorové buňky
Authors CHRISTÉ, Georges (250 France), L. RESTIER (250 France), M. CHAHINE (124 Canada), P. CHEVALIER (250 France) and Michal PÁSEK (203 Czech Republic, guarantor, belonging to the institution).
Edition Lyon, Computers in cardiology 2005, p. 997-1000, 4 pp. 2005.
Publisher IEEE
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30105 Physiology
Country of publisher France
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/05:00019309
Organization unit Faculty of Medicine
ISBN 0-7803-9337-6
ISSN 0276-6574
UT WoS 000236378300251
Keywords in English cardiac cell persistent; sodium current; quantitative modelling
Tags cardiac cell persistent, Quantitative modelling, sodium current
Changed by Changed by: doc. Ing. Michal Pásek, Ph.D., učo 46541. Changed: 27/4/2011 14:45.
Abstract
In LQT3 patients, SCN5A mutations were found that lead to a small fraction of persistent hNav1.5 current. We explored the effects of such a change on the intracellular ionic homeostasis and arrhythmogenesis in a model of guinea-pig cardiac ventricular cell.
Abstract (in Czech)
SCN5A mutace sodíkových kanálů nalezené u pacientů se syndromem LQT3 způsobují vznik malé frakce persistentního hMav1.5 proudu. Cílem práce bylo vyšetřit účinek této mutace na intracelulární iontovou rovnováhu a arytmogenezi u modelu srdeční komorové buňky morčete.
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Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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