Detailed Information on Publication Record
2005
Comparing genomes of pathogenic and non-pathogenic spirochetes: DNA-microarray hybridizations, whole genome fingerprinting and DNA sequencing.
ŠMAJS, David, Petra MATĚJKOVÁ, Michal STROUHAL, S.J. NORRIS, G.M. WEINSTOCK et. al.Basic information
Original name
Comparing genomes of pathogenic and non-pathogenic spirochetes: DNA-microarray hybridizations, whole genome fingerprinting and DNA sequencing.
Name in Czech
Srovnání genomů patogenních a nepatogenních spirochet pomocí DNA-microarray hybridizace, whole genome fingerprintingu a DNA sekvenování.
Authors
ŠMAJS, David (203 Czech Republic, guarantor), Petra MATĚJKOVÁ (203 Czech Republic), Michal STROUHAL (203 Czech Republic), S.J. NORRIS (840 United States of America) and G.M. WEINSTOCK (840 United States of America)
Edition
Abstract Book of NATO Advanced Research Workshop on Molecular Biology of Spirochetes, 2005
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
Genetics and molecular biology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/05:00013211
Organization unit
Faculty of Medicine
Keywords in English
Treponema pallidum ssp. pallidum; Treponema pallidum ssp. pertenue; Treponema paraluiscuniculi
Změněno: 8/4/2010 15:52, prof. MUDr. David Šmajs, Ph.D.
V originále
Genomes of closely related treponemes, Treponema pallidum ssp. pallidum (strains Nichols and SS14) and Treponema pallidum ssp. pertenue (Samoan D) were compared with the genome of Treponema paraluiscuniculi (strain Cuniculi A) using comparative genomic techniques. T. pallidum ssp. pallidum is the causative agent of highly invasive human disease syphilis, T. pallidum ssp. pertenue is the causative agent of yaws and T. paraluiscuniculi is not pathogenic to humans. When compared to Nichols genome, 1, 8 and 34 differences in the BamH I target restriction sites and 3, 7 and 20 indels were found in the genome of SS14, Samoan D and T. paraluiscuniculi, respectively.
In Czech
Genomy blízce příbuzných treponem, Treponema pallidum ssp. pallidum (kmenů Nichols a SS14) a Treponema pallidum ssp. pertenue (Samoan D) byly porovnány s genomem Treponema paraluiscuniculi (kmenCuniculi A) s použitím technik komparativní genomiky. Ve srovnání s kmenem Nichols jsme nalezli, 1, 8 a 34 změn pro cílovou sekvenci restriktázy BamH I a 3, 7 a 20 inzercí a delecí v genomech SS14, Samoan D a T. paraluiscuniculi.
Links
GA310/04/0021, research and development project |
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MSM0021622415, plan (intention) |
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NI7351, research and development project |
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