Detailed Information on Publication Record
2005
Genomics of Treponema.
WEINSTOCK, G.M., David ŠMAJS, Petra MATĚJKOVÁ, S.J. NORRIS, T. PALZKILL et. al.Basic information
Original name
Genomics of Treponema.
Name in Czech
Genomika rodu Treponema.
Authors
WEINSTOCK, G.M. (840 United States of America), David ŠMAJS (203 Czech Republic, guarantor), Petra MATĚJKOVÁ (203 Czech Republic), S.J. NORRIS (840 United States of America), T. PALZKILL (840 United States of America), T.J. ALBERT (840 United States of America) and E. SODERGREN (840 United States of America)
Edition
Abstract Book of NATO Advanced Research Workshop on Molecular Biology of Spirochetes, 2005
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
Genetics and molecular biology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/05:00013213
Organization unit
Faculty of Medicine
Keywords in English
T. pallidum pallidum; T. pallidum pertenue; T. pallidum endemicum; T. carateum
Změněno: 8/4/2010 16:09, prof. MUDr. David Šmajs, Ph.D.
V originále
The genus Treponema contains a number of disease-causing species. This includes T. pallidum pallidum (syphilis), T. pallidum pertenue (yaws), and T. pallidum endemicum (endemic syphilis, bejel) as well as T. carateum (pinta), T. paraluiscuniculi (rabbit treponematosis), and T. denticola (associated with periodontal disease). Many of these organisms differ from each other in only a few percent of their sequence, as judged by older hybridization studies, yet cause distinct diseases and pathologies. It is likely that the genetic bases for these pnenotypic differences results from subtle changes, possibly single base changes, rather than gain or loss of blocks of genes. Our aim has been to catalog genomic differences between these organisms as a starting point to pinpointing the genetic differences responsible for the infection phenotypes. We have sequenced several of these bacteria, using conventional as well as new methods, and have also performed genome wide comparisons by fingerprinting methods.
In Czech
Rod Treponema zahrnuje řadu patogenních bakterií. T. pallidum pallidum způsobuje syfilis, T. pallidum pertenue frambézii (yaws), T. pallidum endemicum (endemická syfilis, bejel) a T. carateum (pinta). T. paraluiscuniculi způsobuje treponemální onemocnění králíků a T. denticola je asociována s periodontálním onemocněním. V naší práci srovnáváme genetickou příbuznost patogenních spirochet s použitím metod funkční a komparativní genomiky.
Links
| GA310/04/0021, research and development project |
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| MSM0021622415, plan (intention) |
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| NI7351, research and development project |
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