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@article{622450,
author = {Benešová, Yvonne and Novotná, Hana and Beránek, M. and Štourač, Pavel and Hladíková, Magdaléna},
article_location = {Basingstoke},
article_number = {Suppl. 1},
keywords = {Metalloproteinases; multiple sclerosis; immunopathogenesis},
language = {eng},
issn = {1352-4585},
journal = {Multiple sclerosis},
title = {Matrixmetalloproteinases in the immunopathogenesis of multiple sclerosis},
volume = {11},
year = {2005}
}
TY - JOUR
ID - 622450
AU - Benešová, Yvonne - Novotná, Hana - Beránek, M. - Štourač, Pavel - Hladíková, Magdaléna
PY - 2005
TI - Matrixmetalloproteinases in the immunopathogenesis of multiple sclerosis
JF - Multiple sclerosis
VL - 11
IS - Suppl. 1
SP - 120
EP - 120
PB - Arnold
SN - 13524585
KW - Metalloproteinases
KW - multiple sclerosis
KW - immunopathogenesis
N2 - Multiple sclerosis (MS) is a chronic autoimmune disorder of the CNS. Matrixmetalloproteinases (MMPs) play a key role in the immunopathogenesis of MS and are significant contributors to the progression of the inflammatory process. There are 23 MMPs known to play a role in the MS disease process. The aim of this study was to analyse the activity of MMP-2 and TIMP-2 in multiple sclerosis and to assess their relationship to the form of the disease. There were 50 patients with definite multiple sclerosis (mean age: 36+/-8 years, mean EDSS score 3.8+/-1.8) studied. Serum levels of MMP-2 and TIMP-2 were quantified by ELISA method in 30 patients with relapsing-remitting form, 10 with definite secondary progressive and 10 with primary progressive form of the disease and compared with those of 50 healthy controls (mean age 36+/-9 years). Mean protein serum levels in control group were: TIMP-2: 47.9 ng/ml, MMP-2: 1887.6 ng/ml. In MS group serum levels were: TIMP-2 46.1 ng/ml, MMP-2 1967.7 ng/ml, in MS group with progressive, and TIMP-2 40.5 ng/ml, MMP-2 2238.5 ng/ml in relapsing-remitting form. There were no statistically significant difference between control and MS groups. The levels of MMP-2 and TIMP-2 were, however, significantly higher in the progressive form of the disease when compared with the relapsing-remitting form of the disease (p< 0.05), probably as a marker of destruction of the nervous tissue.. MMPs ssems to be a promising biological markers which indicate the disease form.
ER -
BENEŠOVÁ, Yvonne, Hana NOVOTNÁ, M. BERÁNEK, Pavel ŠTOURAČ a Magdaléna HLADÍKOVÁ. Matrixmetalloproteinases in the immunopathogenesis of multiple sclerosis. \textit{Multiple sclerosis}. Basingstoke: Arnold, 2005, roč.~11, Suppl. 1, s.~120. ISSN~1352-4585.
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