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@article{628964,
author = {Pazderski, Leszek and Lakomska, Iwona and Wojtczak, Andrzej and Szlyk, Edward and Sitkowski, Jerzy and Kozerski, Lech and Kamieński, Bohdan and Koźmiński, Wiktor and Toušek, Jaromír and Marek, Radek},
article_location = {Amsterdam},
article_number = {1},
keywords = {6-mercaptopurine; tautomerism; 15N NMR; 15N CPMAS; HECADE},
language = {eng},
issn = {0022-2860},
journal = {Journal of Molecular Structure},
title = {The studies of tautomerism in 6-mercaptopurine derivatives by 1H-13C, 1H-15N NMR and 13C, 15N CP/MAS-experimental and quantum chemical approach},
url = {http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5262&_auth=y&_acct=C000045159&_version=1&_urlVersion=0&_userid=835458&md5=94c7f6972ea3add66a0adb8beebaee23},
volume = {785},
year = {2006}
}
TY - JOUR
ID - 628964
AU - Pazderski, Leszek - Lakomska, Iwona - Wojtczak, Andrzej - Szlyk, Edward - Sitkowski, Jerzy - Kozerski, Lech - Kamieński, Bohdan - Koźmiński, Wiktor - Toušek, Jaromír - Marek, Radek
PY - 2006
TI - The studies of tautomerism in 6-mercaptopurine derivatives by 1H-13C, 1H-15N NMR and 13C, 15N CP/MAS-experimental and quantum chemical approach
JF - Journal of Molecular Structure
VL - 785
IS - 1
SP - 205-215
EP - 205-215
PB - Elsevier
SN - 00222860
KW - 6-mercaptopurine
KW - tautomerism
KW - 15N NMR
KW - 15N CPMAS
KW - HECADE
UR - http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5262&_auth=y&_acct=C000045159&_version=1&_urlVersion=0&_userid=835458&md5=94c7f6972ea3add66a0adb8beebaee23
N2 - Tautomerism in 6-mercaptopurine (6mpH), 2,6-dimercaptopurine (2,6dmp) and 6-mercaptopurine-9-riboside (6mp-9rb) was studied in the solution with 2D NMR methods-1H-13C HMBC and 1H-15N HMQC. The 15N NMR signals were assigned and the distribution of mobile protons proposed on the basis of 13C, 15N chemical shifts and JHC, JHN coupling constants, determined with HECADE. These heterocycles appear in DMSO-d6 as the thionic species with predominance of the following tautomers: N(1)H, N(7)H for 6mpH; N(1)H, N(3)H, N(7)H for 2,6dmp; N(1)H for 6mp-9rb. Quantum-chemical NMR calculations by GIAO method(RHF/6-31G**//B3LYP/6-31G**) allowed to evaluate the ratios of N(7)H, N(9): N(7), N(9)H tautomeric forms as ca. 3:1 for 6mpH and nearly 10:0 for 2,6dmp. The 13C and 15N CPMAS spectra were measured for solid 6mpHH2O, anhydrous 6mpH, 2,6dmp and 6-mercaptopurinium chloride (6mpH2Cl), confirming the thionic character of all compounds. The 15N chemical shifts in the solid phase were calculated (B3LYP/631G**) for 6mpHH2O and 6mpH2Cl, basing on the re-determined single crystal X-ray data (optimised with RHF/3-21G**).
ER -
PAZDERSKI, Leszek, Iwona LAKOMSKA, Andrzej WOJTCZAK, Edward SZLYK, Jerzy SITKOWSKI, Lech KOZERSKI, Bohdan KAMIE$\backslash$'NSKI, Wiktor KO$\backslash$'ZMI$\backslash$'NSKI, Jaromír TOUŠEK and Radek MAREK. The studies of tautomerism in 6-mercaptopurine derivatives by 1H-13C, 1H-15N NMR and 13C, 15N CP/MAS-experimental and quantum chemical approach. \textit{Journal of Molecular Structure}. Amsterdam: Elsevier, 2006, vol.~785, No~1, p.~205-215. ISSN~0022-2860.
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