IZAKOVIČOVÁ HOLLÁ, Lydie, Andrea STEJSKALOVÁ, Vladimír ZNOJIL and Anna VAŠKŮ. Association study of promoter polymorphisms within NOS3 gene with allergic diseases. International Archives of Allegy and Immunology. Basel (Switzerland): S. Karger AG, 2006, vol. 141, No 2, p. 103-109. ISSN 1018-2438. |
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@article{630346, author = {Izakovičová Hollá, Lydie and Stejskalová, Andrea and Znojil, Vladimír and Vašků, Anna}, article_location = {Basel (Switzerland)}, article_number = {2}, keywords = {asthma; gender difference; nitric oxide; polymorphism; NOS3; eNOS; endothelial nitric oxide synthase}, language = {eng}, issn = {1018-2438}, journal = {International Archives of Allegy and Immunology}, title = {Association study of promoter polymorphisms within NOS3 gene with allergic diseases}, volume = {141}, year = {2006} }
TY - JOUR ID - 630346 AU - Izakovičová Hollá, Lydie - Stejskalová, Andrea - Znojil, Vladimír - Vašků, Anna PY - 2006 TI - Association study of promoter polymorphisms within NOS3 gene with allergic diseases JF - International Archives of Allegy and Immunology VL - 141 IS - 2 SP - 103-109 EP - 103-109 PB - S. Karger AG SN - 10182438 KW - asthma KW - gender difference KW - nitric oxide KW - polymorphism KW - NOS3 KW - eNOS KW - endothelial nitric oxide synthase N2 - Nitric oxide (NO) is an important mediator of physiologic and pathologic processes in the airways. On this basis, we hypothesised that polymorphisms in the NOS3 gene could be associated with the disease process.Two promoter variants (-786C/T and -691C/T) were examined in a Caucasian Czech population of allergic patients [n=671, with a subgroup of asthmatics (n=305)] and healthy controls (n=334) using PCR-RFLP analyses. NOS3 -786C/T and -691C/T were not associated with allergic diseases or asthma. However, the 786 variant was significantly associated with asthma in men (p < 0.01, Pcorr < 0.05) but not in women. NOS3 -691C/T was found to be in strong linkage disequilibrium with -786C/T, and the distribution of combined genotypes was marginally different between the asthmatic and control men. Our results suggest that NOS3 gene variants may be one of the factors that participate in the pathogenesis of asthma in men. ER -
IZAKOVIČOVÁ HOLLÁ, Lydie, Andrea STEJSKALOVÁ, Vladimír ZNOJIL and Anna VAŠKŮ. Association study of promoter polymorphisms within NOS3 gene with allergic diseases. \textit{International Archives of Allegy and Immunology}. Basel (Switzerland): S. Karger AG, 2006, vol.~141, No~2, p.~103-109. ISSN~1018-2438.
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