| PETRÁŠEK, J., J. MRAVEC, R. BOUCHARD, J. BLAKESLEE, M. ABAS, D. SEIFERTOVÁ, J. WISNIEWSKA, Z. TADELE, M. ČOVANOVÁ, P. DHONUKSHE, P. SKŮPA, E. BENKOVÁ, L. PERRY, P. KŘEČEK, O.R. LEE, G. FINK, M. GEISLER, A. MURPHY, C. LUSCHNIG, E. ZAŽÍMALOVÁ and J. FRIML. PIN proteins perform a rate-limiting function in cellular auxin efflux. Science. 2006, vol. 2006, Apr 6, p. advanced on line, 8 pp. ISSN 0036-8075. |
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@article{630451,
author = {Petrášek, J. and Mravec, J. and Bouchard, R. and Blakeslee, J. and Abas, M. and Seifertová, D. and Wisniewska, J. and Tadele, Z. and Čovanová, M. and Dhonukshe, P. and Skůpa, P. and Benková, E. and Perry, L. and Křeček, P. and Lee, O.R. and Fink, G. and Geisler, M. and Murphy, A. and Luschnig, C. and Zažímalová, E. and Friml, J.},
article_number = {Apr 6},
keywords = {auxin transport; auxin efflux; PIN proteins; Arabidopsis},
language = {eng},
issn = {0036-8075},
journal = {Science},
title = {PIN proteins perform a rate-limiting function in cellular auxin efflux},
volume = {2006},
year = {2006}
}
TY - JOUR
ID - 630451
AU - Petrášek, J. - Mravec, J. - Bouchard, R. - Blakeslee, J. - Abas, M. - Seifertová, D. - Wisniewska, J. - Tadele, Z. - Čovanová, M. - Dhonukshe, P. - Skůpa, P. - Benková, E. - Perry, L. - Křeček, P. - Lee, O.R. - Fink, G. - Geisler, M. - Murphy, A. - Luschnig, C. - Zažímalová, E. - Friml, J.
PY - 2006
TI - PIN proteins perform a rate-limiting function in cellular auxin efflux
JF - Science
VL - 2006
IS - Apr 6
SP - advanced on line
EP - advanced on line
SN - 00368075
KW - auxin transport
KW - auxin efflux
KW - PIN proteins
KW - Arabidopsis
N2 - Intercellular flow of the phytohormone auxin underpins multiple developmental processes in plants. Plant-specific PIN proteins and several PGP transporters are crucial factors in auxin transport-related development, yet PINs molecular function remains unknown. Here we show that PINs mediate auxin efflux from mammalian and yeast cells without needing additional plant-specific factors. Conditional gain-of-function alleles and quantitative measurements of auxin accumulation in Arabidopsis and tobacco cultured cells revealed that the action of PINs in auxin efflux is distinct from PGPs, rate-limiting, specific to auxins and sensitive to auxin transport inhibitors. This suggests a direct involvement of PINs in catalyzing cellular auxin efflux.
ER -
PETRÁŠEK, J., J. MRAVEC, R. BOUCHARD, J. BLAKESLEE, M. ABAS, D. SEIFERTOVÁ, J. WISNIEWSKA, Z. TADELE, M. ČOVANOVÁ, P. DHONUKSHE, P. SKŮPA, E. BENKOVÁ, L. PERRY, P. KŘEČEK, O.R. LEE, G. FINK, M. GEISLER, A. MURPHY, C. LUSCHNIG, E. ZAŽÍMALOVÁ and J. FRIML. PIN proteins perform a rate-limiting function in cellular auxin efflux. \textit{Science}. 2006, vol.~2006, Apr 6, p.~advanced on line, 8 pp. ISSN~0036-8075.
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