Detailed Information on Publication Record
2006
A keratinocyte-produced inhibitor is differentially active against two isoforms of MSF
JONES, Sarah, Margaret FLORENCE, Ian ELLIS, Richard KAY, Jacqueline COX et. al.Basic information
Original name
A keratinocyte-produced inhibitor is differentially active against two isoforms of MSF
Name in Czech
Inhibitor produkovaný keratinocyty rozdílně inhibuje dvě isoformy MSF
Authors
JONES, Sarah (826 United Kingdom of Great Britain and Northern Ireland), Margaret FLORENCE (826 United Kingdom of Great Britain and Northern Ireland), Ian ELLIS (826 United Kingdom of Great Britain and Northern Ireland), Richard KAY (826 United Kingdom of Great Britain and Northern Ireland), Jacqueline COX (826 United Kingdom of Great Britain and Northern Ireland), Kateřina KAŇKOVÁ (203 Czech Republic, guarantor), Seth SCHOR (826 United Kingdom of Great Britain and Northern Ireland) and Ana SCHOR (826 United Kingdom of Great Britain and Northern Ireland)
Edition
British Microcirculation Society Meeting 2006, 2006
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
Genetics and molecular biology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/06:00016675
Organization unit
Faculty of Medicine
Keywords in English
MSF; fibronectin; migration
Tags
Změněno: 2/4/2010 15:10, prof. MUDr. Kateřina Kaňková, Ph.D.
V originále
MSF is a truncated (70kDa) isoform of fibronecting displaying number of potent biactivities mediated by IGD-amino acid motif. Two MSF isoforms, differing in terms of 15 amino acid deletion in a module II-1, have been identified. While IGD-mediated bioactivities od both isoforms are identical, deleted isoform (MSF-aa) is not inhibited by recently characterised inhibitor produced by normal keratinocytes. Furthermore, various cancer cell lines produce MSF activity which is not inhibited or partly inhibited by MSF inhibitor.
In Czech
Práce popisuje objev jedné z isoforem zkrácené formy fibronektinu (s funkcí matrikinu), která na rozdíl od ostatních není inhibovatelná fyziologickým inhibitorem produkovaným normálními keratinocyty. Různé nádorové buněčné linie produkují MSF aktivitu, kterou není možno inhibovat tímto nově popsaným inhibitorem.
Links
| LZ1K03019, research and development project |
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