Detailed Information on Publication Record
2006
Molecular biology of ADHD: an association study of DAT1, DRD2, DRD4, COMT and MAOB gene polymorphisms with hyperactive disorder in children
ŠTAIF, Radim, Ivana DRTÍLKOVÁ, Renáta PITELOVÁ, Omar ŠERÝ, Pavel THEINER et. al.Basic information
Original name
Molecular biology of ADHD: an association study of DAT1, DRD2, DRD4, COMT and MAOB gene polymorphisms with hyperactive disorder in children
Name in Czech
Molekulárně-biologické příčiny ADHD: asociační studie polymorfizmů genů pro DAT1, DRD2, DRD4, COMT a MAOB
Authors
ŠTAIF, Radim (203 Czech Republic), Ivana DRTÍLKOVÁ (203 Czech Republic), Renáta PITELOVÁ (203 Czech Republic), Omar ŠERÝ (203 Czech Republic, guarantor) and Pavel THEINER (203 Czech Republic)
Edition
Abstract book 2006. Riga, Latvia, 3rd International Biology Students Conference 2006, April 6.-9. 2006, p. 47-47, 50 pp. 2006
Publisher
Latvias Universiatates Biologijas Studentu Asociacia (LUBSA)
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14310/06:00016760
Organization unit
Faculty of Science
Keywords in English
ADHD; DAT1; DRD2; DRD4; COMT; MAOB; gene; polymorphism
Změněno: 1/3/2007 17:10, prof. RNDr. Omar Šerý, Ph.D.
V originále
Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with significant genetic contribution, one of the most commonly diagnosed neurobehavioral disorders in a childhood. The hyperactivity is the disorder of behavior affecting 3-6% of school age children wordwide; the main symptoms are inattention, impulsivity and distractibility. In the past few years, interest in the molecular psychiatry genetics of ADHD has grown enormously, with many groups searching for susceptibility genes. Dopamine genes have been the initial candidates based on the site of the action of the psychostimulant drugs. We have investigated whether there is an association of dopamine system candidate genes DAT1, DRD2, DRD4, COMT and MAOB with ADHD. The aim of our case-control study was to determine whether the ADHD boys (118) have different genotype and alelic frequencies of examined genes compared to controls (153). No significant differences were found between groups of boys in polymorphism genes DRD4, COMT and MAOB (p > 0.05). The statistical analysis using Fisher exact test did not confirme the association of the previously possitive investigated 10-repeat allele or 10/10 genotype of DAT1 gene (p = 0.531). However, we found the association of long 10/11 genotype of DAT1 gene (p = 0.0063). The difference in the frequency of 10/11 genotype may signify that rare 11 allele may increase higher risk of ADHD. For DRD2, ADHD probands were more likely than controls to have the A1 allele and genotype A1A1 (p = 0.0013). Our results showed that ADHD in Czech children population is associated with TaqI A polymorphism of DRD2 gene, the presence of DRD2 A1 allele increase the risk of ADHD.
In Czech
Hyperaktivita je mnohočetná porucha vyskytující se hojně u dětí mladšího školního věku - objevuje se u 3-6% dětské populace. V naší asociační studii jsme zkoumali polymorfní geny pro DAT1, DRD2, DRD4, COMT a MAOB. Polymorfizmy těchto kandidátních genů dopaminového systému mohou stát za příčinami vzniku této poruchy. Ve studii porovnávající genotypové a alelické frekvence skupin hyperaktivních chlapců s kontrolní skupinou chlapců jsme neobjevili signifikantní závislost pro vybrané polymorfizmy genů pro DRD4, COMT a MAOB. Statisticky signifikantní rozdíl mezi skupinami byl naopak nalezen pro TaqI A polymorfizmus genu pro DRD2 (p = 0,0013). Dále byl mezi skupinami objeven signifikantní rozdíl (p = 0,0063) v genotypové frekvenci řídce se vyskytujícího genotypu 10/11 VNTR polymorfizmu genu pro DAT1, naopak jsme nepotvrdili v dřívějších studiích nalezenou signifikantní závislost pro genotyp 10/10 (p = 0,531).
Links
| MSM0021622413, plan (intention) |
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| NF6520, research and development project |
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